In vivo Experiment of Extracellular Acidic Polysaccharide (EAPS) from Microcystic aeruginosa on Tumour Cells

Abstract

Abstract: EAPSⅠ and EAPSⅡextracted from M.aeruginosa had inhabiting effects on tumor cells in cultivating normal and tumor cells and cancer mice. Results indicated that EAPSⅠ and EAPSⅡ are all toxic to cells of HEK293 but the toxicity is less than that of 5-FU. The growth of Hela, SP2-0 or U251 cells is all evidently restrained by them and the inhabiting effects go up gradually as the treatment time continues, and the highest inhabiting effects occur on the 6th or 8th day. EAPSⅠ and EAPSⅡ accelerate the death of Hela cells; and both show no significant differences with 5-FU on prolonging mice life by testing on S180 tumor cells.

Key words: , M.aeruginosa； EAPS(extracellular acidicpolysaccharide)； activity of anti-tumor； SP2-0；

ZHANG Ling, MEI Qiu-Hong, XUE Hua-Jie, ZHOU Yao-Ming, LU Chang-Mei, WU Guo-Rong. In vivo Experiment of Extracellular Acidic Polysaccharide (EAPS) from Microcystic aeruginosa on Tumour Cells[J]. FOOD SCIENCE, 2007, 28(6): 311-315.

[1]	LIU Xiaohui, XU Lijuan, LI Yongge, LIU Huishuang, YANG Xuejuan, SUN Baoshan, LIU Jiang, WEI Ran. Simultaneous Determination of Non-Volatile Flavor Substances in Acid-Hydrolyzed Corn Protein Powder [J]. FOOD SCIENCE, 2016, 37(8): 152-158.
[2]	GAO Yi, ZHOU Guangming, ZHANG Caihong, YU Lu, CHEN Junhua, QIN Hongying. Simultaneous Determination of Six Active Components in Viola yedoensis Makino by HPLC [J]. FOOD SCIENCE, 2016, 37(6): 101-105.
[3]	CHU Zhong, WANG Hairu, ZHANG Yanjun, YAO Jing. GC-MS Analysis of Volatiles in Vanilla Husk Extracted by Headspace Solid-Phase Microextraction [J]. FOOD SCIENCE, 2016, 37(6): 126-131.
[4]	SONG Hui, GENG Zhiming, REN Shuang, WANG Daoying, ZHANG Muhan, SUN Chong, XU Weimin. Simultaneous Determination of 13-HODE, 9,10-DHODE, 9,10-EPODE and 9,10,13-THOD in Cured Meat Products by HPLC-MS/MS [J]. FOOD SCIENCE, 2016, 37(18): 133-140.
[5]	XIE Liyan, LIN Ying*, WU Heng, XU Xiaohui, ZHU Xueqiong. Interaction Mechanism between Acetylated Distarch Adipate and Soymilk on Yuba Membrane [J]. FOOD SCIENCE, 2015, 36(5): 77-82.
[6]	XIE Yuejie1, HE Zhifei2, LI Hongjun1,*. Volatile Flavor Profile of Rabbit Meat Extracted by Three Frequently Used Techniques [J]. FOOD SCIENCE, 2015, 36(24): 147-151.
[7]	ZHANG Xiaoli, MAO Lixin, FAN Sanhong. Synchronous Fluorescence Spectroscopy Combined with Principal Component Analysis to Identify Orange Juice Quality [J]. FOOD SCIENCE, 2015, 36(18): 162-166.
[8]	XIE Jilin, ZHANG Wei*, CHEN Xiaoquan, ZHAO Yahua, ZHU Xi. Analysis of Changes in Aroma Constituents during Storage of Ripe Pu’er Tea [J]. FOOD SCIENCE, 2015, 36(10): 154-157.
[9]	FANG Bowen, QI Ruiting, ZHANG Ying* . Active Components and Antioxidant Activities of Different Parts of Citrus paradise Fruit [J]. FOOD SCIENCE, 2015, 36(10): 158-163.
[10]	YUAN Jiangfeng1, ZHAO Junfeng1, SUN Junjie1, HE Lingmei2, ZHANG Zhiqi3, LIU He1. Determination of Flavonoids and Triterpene Acids in Forsythia suspensa Leaves from Henan and Shanxi Provinces [J]. FOOD SCIENCE, 2015, 36(10): 164-167.
[11]	ZHU Sai-feng, WU Jian-feng, ZHAO Xi-rong. Response Surface Methodology for Optimization of Culture Conditions for the Production of Tetramethylpyrazine by Bacillus subtilis S0507 [J]. FOOD SCIENCE, 2014, 35(9): 218-223.
[12]	WU Run-feng, ZHAO Li*, YUAN Mei-lan, SU Wei, CHEN Li-li, WEN Hui-fang, WANG Xiao-cheng. Quality Change of Surimi of Four Major Chinese Carps before and after Rinsing [J]. FOOD SCIENCE, 2014, 35(9): 132-136.
[13]	HE Yang-yang, ZENG Wei, WANG Qing-long, WANG Da-yun, CHEN Gui-guang, LIANG Zhi-qun*. Optimization of Medium Composition and Fermentation Conditions by Response Surface Methodology for the Production of Poly-γ-Glutamic Acid by Bacillus subtilis [J]. FOOD SCIENCE, 2014, 35(9): 147-151.
[14]	LIU Tao, SUN Jian, GUO Chen, ZHAO Xiao-hong. Comparison of Early Damage of CHO Cells in the Presence of Different Flavonoid Monomers [J]. FOOD SCIENCE, 2014, 35(11): 223-228.
[15]	. Anti-Tumor Activity of Purple Sweet Potato Juice and Its Apoptosis-Inducing Mechanism in HepG2 Cells [J]. FOOD SCIENCE, 2013, 34(1): 263-267.

In vivo Experiment of Extracellular Acidic Polysaccharide (EAPS) from Microcystic aeruginosa on Tumour Cells

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments