Abstract: Objective:To study the inhibition of garlic on the development of fatty liver.Methods:Fatty liver models were induced by CCl4 and chronically feeding with high fat diet containing 10% lard in rats and confirmed by HE dyeing.In addition to the rats of model group,we had other two groups with male and female sub-group in each one — the rats of control group that were fed regularly and the rats of garlic groups that were fed different doses-1%,3%,5%,7% of garlic mash,high fat diet and water with 1% garlic juice.30 days later,the level of triglyceride(TG)and total cholesterol(TC)of liver for different diet groups rats of both genders were analyzed and compared.Results:(1)Compared with model group,the levels of TG and TC in garlic groups were decreased with different extent —for female,TG and TC were significantly decreased for dose 3%,5%,7%,and 5%,7%,respectively;while for male,5% and 7% garlic mash were effective to reduction of TG,and only 7% were effective to reduction of TC.(2)There were significant correlation between dose of garlic mash and reduction of TC(male:R2=0.9742,female:R2=0.9655).Conclusions:Garlic diet had effects on inhibiting the increases of TG and TC of liver in model rats and inhibition effect was different for male and female rats,and female rats were more sensitive to high fat diet and garlic diet.

Key words: non-alcoholic fatty liver, garlic diet, triacylglycerol, total cholesterol