Abstract: Objective:The purpose was to evaluate the efficacy of chitosan and it’s Rhizoma anemarrhenae mixture on regulating blood glucose and advanced glycosylation end products(AGEs)in diabetic mice bodies.Method:Diabetes mellitus model was established by intraeritoneal injecting of alloxan,and the mice were randomly divided into normal group,model group,chitosan group,chitosan + Rhizoma anemarrhenae group(high and low).The mice were treated with drugs intragastrically(ig)for 28 days,the following parameters were evaluated:serum glucose,fructosamine,free fatty acid(FFA),serum advanced glycosylation end products(AGEs),serum SOD and MDA.Results:Compared with normal group,the blood glucose,AGEs,fructosamine,FFA,MDA in model group were increased,while pH and SOD was decreased in the model group.Compared with model group,MDA,blood glucose,AGEs and FFA were reduced,while SOD were increased in chitosan or the higher mixture group,the PH were increased in the treatment groups,and no significant differences were tested of fructosamine in the treatment groups.Conclusion:Chitosan,chitosan + Rhizoma anemarrhenae could protect the diabetic mice by reducing blood glucose and blood AGEs.

Key words: chitosan, Rhizoma anemarrhenae, AGEs, blood glucose, fructosamine