Abstract: A model of exhaustive exercise mice was established,and different dosages of Gynostemma pentaphyllum polysaccharides solution were adminsitered to the test mice by gavage to explore the effects of Gynostemma pentaphyllum polysaccharide on the exhausted mice by determining the activity of antioxidant enzyme and content of lipid peroxidation product(MDA) in some mice tissues.The results showed that Gynostemma pentaphyllum polysaccharides play a role for the enhancement of the antioxidant enzyme activity in some tissues of exhausted mice,and to a certain extent inhibit the lipid peroxidation damage.

Key words: Gynostemma pentaphyllum polysaccharides, exercise fatigue, anti-oxidation