Abstract: Cholesterol-degrading strain was isolated from pickled vegetable and identified as Lactobacillus plantarum by VITEK-32 Automatic Microbe Analytic Systems. In MRS medium with cholesterol, LP1103 strain degrades 42.5% of cholesterol. The effects of LP1103 on the total serum cholesterol (TC), triglycerid (TG), high density lipoprotein-cholesterol (HDL-C), and totalbileacid (TBA) were investigated to artificially-induced mice. The results showed that the mean values of serum TC, TG, and TBA concentrations decrease significantly (p<0.05). According to the results, the risk index of hyperlipemia and athero-genic index of the mouse in test group lower than those of mouse in CK group. And the TC and TBA in faeces increase at the same time, while serum HDL-C concentration, body weight, and liver weight do not significantly increase after 4 w feeding.

Key words: Lactobacillus plantarum, screening, cholesterol degradation, hyperlipidemia model, mechanism