Abstract:

The study aimed to investigate the effect of dietary Eupolyphaga sinensis Walker (EW) and its mutant (columnar Eupolyphaga sinensis Wal ker, CEW) on lipid metabolism in hyperlipidemic mice. Forty eight male Bal b/C mice were randomly divided into 4 groups, normal group (cholesterol free AIN76 diets), model group (1% cholesterol diets), EW group (10% EW powder and 1% cholesterol diets) and CEW group (10% CEW powder and 1% cholesterol diets). After 3 weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) levels were determined. Hepatic lipid concentrations (TG and TC) were also determined. The results showed that CEW significantly decreases the concentrations of serum TC (10%, p<0.05), TG (22%, p<0.001) , LDL-C (16.3%, p<0.05) and hepatic TG (53%, p<0.001). On the other hand, EW does not effect the concentrations of serum TC, LDL-C, hepatic TG or hepatic TC, but significantly decreases the concentrations of serum TG (57%, p<0.001). Both EW and CEW significantly increase HDL-C levels (46%, p<0.001 and 16%, p<0.05 respectively), and decrease atherosclerosis index (33%, p<0.001 and 23%, p<0.001 respectively). In conclusion, this study indicated that there are significant different effects on lipid metabolism in hyperlipidemic mice between EW and CEW. The hypocholesterolemic effect of CEW is better than that of EW, but the hypoglyceridemic effect of EW is better than that of CEW in mice.

Key words: Eupolyphaga sinensis Walker, columnar Eupolyphaga sinensis Walker, hyperlipidemia, atherosclerosis, fatty liver