FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (15): 271-277.doi: 10.7506/spkx1002-6630-201015060

• Nutrition & Hygiene • Previous Articles     Next Articles

Inhibitory Effect of Triacylglycerols on Cultured Human Tumor Cells

FU Wei-chang1,2，GU Xiao-hong2，YU Hui-xin3，TANG Jian2,*，JIANG Zai-liang4   

  1. 1.Institute of Food Science, Jishou University, Jishou 416000, China ；2. State Key Laboratory of Food Science and Technology,
    Jiangnan University, Wuxi 214122, China ；3. Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China；4. Wuxi Furen
    Biologic Science and Technology Co. Ltd., Yixing 214252, China
  • Received:2009-11-05 Online:2010-08-15 Published:2010-12-29
  • Contact: TANG Jian2 E-mail:jiantang06@yahoo.com.cn

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Abstract:

Six fractions of triacylglycerols (TGs) containing conjugated linolenic acids (CLns) were separated from the seed oil of Momordica charantia L. var. abbreviata Ser. (MCVO) and purified by non-aqueous reversed-phase (NARP)-HPLC. The cytotoxic effects of the fractions were further investigated on five human tumor cell lines: ECA-109 (esophageal carcinoma), SGC-7901 (carcinoma ventriculi), Bel-7402 (hepatoma), LS-174-T (colon carcinoma), KB (mouth epidermal carcinoma), and a human normal cell line: L02 (liver cell). α-Eleostearic acid (α-ESA) with a purity of 96% was used as a control. The results demonstrated that the inhibitory effects of the TG fractions on human tumor cell lines were more potent than that of α-ESA, and the effect of TG with three CLns was the weakest. These results suggest that the fatty acid compositions and molecular structures of the TG with more intense stability, which contain CLn, might affect the displayed cytotoxicity to human tumor cell lines.

Key words: seed oil of Momordica charantia L.var. abbreviata Ser., triacylglycerol, conjugated linolenic acid, α- eleostearic acid

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