Abstract:

To evaluate the effect of propolis soft capsules on blood lipid metabolism in rats with high fat diet-induced hyperlipidemia, 60 SD male rats were used as experimental animals and randomly divided into 6 groups designated as propolis groups fed high fat diet and orally administered low, middle and high doses (83.3, 250 mg/(kg bw·d)) and 500 mg/(kg bw·d)) of propolis, negative control group fed normal diet group and orally administered distilled water, positive control group fed high fat diet and orally administered distilled water, and solvent control group fed high fat diet and orally administered vegetable oil. All the animals were conducted corresponding administrations for 30 consecutive days. Tail vein blood was harvested for blood lipid analysis. Results indicated that TC and TG levels in the low- and high-dose propolis groups were significantly lower than those in the solvent control group. The 6 groups did not significantly differ in serum HDL-C level. Therefore, propolis soft capsules have excellent function in regulating blood lipid level in rats with hyperlipidemia.

Key words: propolis soft capsules, blood lipid regulating function, TG, TC