Effects of Grape Seed and Grape Skin Extracts on the Migration of Mouse Mammary Carcinoma Cells

Abstract

Abstract: Objective: To explore the effects of grape seed and grape skin extracts on the migration, viability and proliferation of breast cancer cells. Methods: The viability of mouse mammary carcinoma 4T1 cells was determined by MTT assay and the migration ability by transwell chemotaxis assay. Results: Both grape seed and grape skin extracts significantly reduced the migration of the 4T1 cells in a dose-dependent manner, and exhibited an obvious inhibitory effect on cell migration at a concentration as low as 5μg/mL. The extracts also obviously inhibited the viability and proliferation of the 4T1 cells with IC50 (half maximal inhibitory concentration) of 65.427μg/mL and 72.408μg/mL, respectively.

Key words: grape seed and grape skin extracts, mouse mammary carcinoma cells, viability, migration

CLC Number:

Q279

References

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