Effects of Different Factors on Zeta Potential of Medium-Chain Fatty Acid Liposomes

Abstract

Abstract: Zeta potential is an important measure of the stability of liposomes. The purpose of this study was to extend our previous research to investigate the effects of ecithin type, lipid concentration, Tween-80 concentration, pH, metal ion type, and metal ion concentration on Zeta potential of medium-chain fatty acid liposomes. The highest absolute value of Zeta potential (51.08 mV) was observed for the medium-chain fatty acid liposomes obtained from soybean lecithin at a concentration of 8 g/100 mL and Tween-80 at a mass ratio to soybean lecithin of 3:10. Increasing environmental cationic valence or ion concentration led to a gradual increase in the absolute value of Zeta potential of medium-chain fatty acid liposomes. Medium-chain fatty acid liposomes were the most stable in a slightly neutral environment (pH 7, 8) and its absolute value of Zeta potential was approximately 50 mV. Conversely, the worst stability was obtained in acidic (pH 1, 2) and alkaline (pH 13) environments and as a result, the Zeta potential was closed to 0 mV.

Key words: Zeta potential, medium-chain fatty acid liposomes, affecting factors, stability.

CLC Number:

R944.1

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