FOOD SCIENCE ›› 2013, Vol. 34 ›› Issue (3): 158-162.

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Screening of a high lovastatin-producing Aspergillus terreus mutant by UV combined with heavy-ion beams irradiation

  

  • Received:2011-10-13 Revised:2013-01-05 Online:2013-02-15 Published:2017-12-29

Abstract: In the present study, heavy-ion beam combined with ultraviolet irradiation were used to mutagenize Aspergillus terreus CA99 for selecting a high yield lovastatin mutant. As a result, a mutant designated as A. terreus UV150-3 was isolated. Under submerged fermentation, the maximum lovastatin production of A. terreus UV150-3 was 966.3 ug/mL, which was 5.6 times than that of the original strain A. terreus CA99. The heredity characters of the mutant was stable after successive five generations.

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