[1] Endo A. Monacolin K, a new hypocholesterolemic a-gent produced by a Monascus species[J]. J Antibiot, 1979, 32(8): 852–854.[2] Casas López JL, Sánchez Pérez JA, Fernández Sevilla JM, et al. Production of lovastatin by Aspergillus terreus: effects of the C:N ratio and the principal nutrients on growth and metabolite production[J]. Enzyme Microb Technol, 2003, 33: 270–277.[3] Barrios-González J, Miranda R U. Biotechnological production and applications of statins[J]. Appl Microbiol Biotechnol, 2010, 85: 869–883.[4] 靳建忠, 王慧娟, 孔维甲, 等. 紫外诱变选育出芽短梗霉高产普鲁兰糖白化突变菌株.食品科学, 2011, 32(11): 187-191.[5] 周波, 王菊芳, 吴振强, 等. 高产红曲黄色素菌株的选育[J]. 微生物学通报, 2008, 35(12): 1909–1914.[6] 虞龙, 张宁. 离子注入微生物诱变育种的研究与应用进展[J]. 微生物学杂志 , 2005, 25(2) 80–83.[7] Li SW, Li M, Song HP, et al. Induction of a high-yield lovastatin mutant of Aspergillus terreus by 12C6+ heavy-ion beam irradiation and the influence of culture conditions on lovastatin production under submerged fermentation[J]. Appl Biochem and Biotechnol. 2011, DOI 10.1007/s12010-011-9308-x.[8] Lai L S T, Pan C C, Tzeng B K. The influence of medium design on lovastatin production and pellet formation with a high-producing mutant of Aspergillus terreus in submerged cultures[J]. Process Biochem, 2003, 38: 1317–1326.[9] Bizukojc M, Ledakowicz S. The morphological and physiological evolution of Aspergillusterreus mycelium in the submerged culture and its relation to the formation of secondary metabolites[J]. World J Microbiol Biotechnol, 2010, 26: 41–54.[10] 贾志华, 张小里, 曹学君, 等. 复合氮源对土曲霉洛伐他汀生物合成的影响[J]. 西北农林科技大学学报(自然科学版), 2010, 38: 159–164.[11] Casas López JL, Sánchez Pérez JA, Fernández Sevilla JM, et al. Production of lovastatin by Aspergillus terreus: effects of the C:N ratio and the principal nutrients on growth and metabolite production[J]. Enzyme Microb Technol, 2003, 33: 270–277.[12] Lai LST, Huang CS, Lo CC. Effect of lastose and glucose on production of itaconic acid and lovastatin by Aspergillus turreus ATCC 20542[J]. J Biosci Bioeng, 2007, 104(1): 9–13.[13] Jia ZH, Zhang XL. Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreus in chemically de?ned medium[J]. World J Microbiol Biotechnol, 2009, 25: 1235–1241.[14] 张小茜, 周富荣, 石济民. 高效液相色谱法测血脂康胶囊及红曲中洛伐他汀的含量[J]. 中国中药杂志, 1997, 22(4):222-224.[15] 黄卓, 李东栋. 洛伐他汀最新研究进展[J]. 中国生化药物杂志, 2010, 31(2): 144–146.[16] 蒋世春. 提高洛伐他汀产生菌生物合成能力的研究[J]. 生物学杂志, 2004, 2(5): 38–39.[17] 陈芝, 林文, 宇萍, 等. 通过红曲霉-土曲霉属间原生质体融合提高Monacolin K产量[J].自然科学进展, 2007, 17(4): 536–540.[18] Park JW, Lee JK, Kwon TJ, et al. Bioconversion of compactininto pravastatin by Streptomyces sp[J]. Biotechnol Lett, 2003, 25: 1827–1831.[19] Xie X, Pashkov I, Gao X, et al. Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalyctic activity[J]. Biotechnol Bioeng, 2009, 102:20–28.[20] 陈永浩, 王强. 透明质酸生产菌的诱变选育[J]. 微生物学通报, 2009, 36(2): 205–210. |