Inhibitory Effect of Ethanol Extract from Propolis onα-Glucosidase

doi:10.7506/spkx1002-6630-201105024

FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (5 ): 108-110.doi: 10.7506/spkx1002-6630-201105024

• Basic Research • Previous Articles Next Articles

Inhibitory Effect of Ethanol Extract from Propolis onα-Glucosidase

ZHANG Hong-cheng1，SUN Qing-shen2，WANG Guang-xin1,3，YOU Ying-jie2，DONG Jie1,*

1. Bee Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100093, China；2. College of Life Science,
Heilongjiang University, Harbin 150080, China；3. College of Food Science and Technology, Nanjing Agricultural University,
Nanjing 210095, China

Received:2010-06-30 Revised:2011-02-14 Online:2011-03-15 Published:2011-03-03
Contact: ZHANG Hong-cheng E-mail:zzhc@sohu.com

Abstract

Abstract: In order to explore the mechanism by which propolis controls postprandial blood glucose, the inhibitory effect of ethanol extract from propolis (EEP) on α-glucosidase was evaluated by using α-glucosidase inhibition model in this paper. Inhibitory kinetic parameters were determined by Lineweaver-Burk plot. The results indicated that the median inhibitory concentration (IC50) of EEP was (0.8260 ± 0.1754) mg/mL and the inhibition constant (KI) was (0.0265 ± 0.0060) mg/mL. Kinetic analysis showed that the inhibitory mechanism of EEP on α-glucosidase was a typical noncompetitive inhibition. Therefore, propolis seems to be a healthy food choice for the adjustment of blood glucose.

Key words: propolis, α-glucosidase, noncompetitive inhibition

CLC Number:

TS218

ZHANG Hong-cheng1，SUN Qing-shen2，WANG Guang-xin1,3，YOU Ying-jie2，DONG Jie1,*. Inhibitory Effect of Ethanol Extract from Propolis onα-Glucosidase[J]. FOOD SCIENCE, 2011, 32(5 ): 108-110.

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Inhibitory Effect of Ethanol Extract from Propolis onα-Glucosidase

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