Abstract: The preparation of α-tocopherol/β-cyclodextrin complex by supercritical carbon dioxide impregnation technology was studied. The effects of process parameters, including pressure, temperature and reaction time on α-tocopherol loading and the disperability of α-tocopherol/β-cyclodextrin complex in water were studied. The determination of α-tocopherol loading was carried out using ultraviolet spectrophotometer, and FTIR, DSC and TGA were used for the characterization of α-tocopherol/β-cyclodextrin complex. The results showed that α-tocopherol loading first rose and then declined with increasing pressure and temperature, and reached up to 38.7% at 35 ℃, 18 MPa and impregnation time of 1 h, and that the prepared complex could disperse homogeneously in water.

Key words: supercritical CO2 impregnation technology, α-tocopherol, β-cyclodextrin, complex