Abstract: In order to provide foundation for application of rape pollen in control of alcoholic liver injury, effects of rape pollen and its extracts on pathohistology of rat with alcoholic liver injury were studied. The rats were administered orally distillate spirit to induce alcoholic liver injury. Control group could take food and water freely. After therapy with rape pollen and its extracts, livers of rats were isolated. The liver slices were dyed by routine HE and observed by light microscopy. In model group, normal structure of liver of model group rat disappears, hepatic cell shows obvious hydopic and fatty change and focus necrosis, and lymphocyte and lymphomonocyte infiltrate. In therapy group, damage of liver shows extenuation at different degrees. The liver damage treated by acetoacetate, n-butanol or distilled water extracts shows significant extenuation with clear structure of liver tissue without obvious pathological change. These experimental results indicated that rape pollen and its extracts have protective effects on alcoholic liver injury of rat. The effects of its acetoacetate, n-butanol and distilled water extracts are obvious.

Key words: alcoholic liver injury, rape pollen, histology