FOOD SCIENCE ›› 2008, Vol. 29 ›› Issue (8): 188-190.

Previous Articles     Next Articles

Study on Production Technology of Riboflavin Sodium Phosphate

 SUN  Wen-Jing, WEI  Zhuan, YU  Si-Lian, ZHOU  Qiang, HUANG  Da-Ming   

  1. 1.College of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,China;2.Parchn Sodium Isovitamin C Co. Ltd.,Dexing 334221,China;3.Department of Pharmaceutical,Hebei Chemical and Pharmaceutical College,Shijiazhuang 050026,China
  • Online:2008-08-15 Published:2011-08-26

Abstract: Effects of riboflavin-phosphorus oxychloride-water ratio,phosphorylation reaction time,and reaction temperature on preparation of riboflavin sodium phosphate were investigated. The results showed that reaction product of riboflavin and 4-times moles of phosphorus oxychloride reacting for 2 h at about 35 ℃ in the mixture of pyridine and acetonitrile as a solvent is hydrolyzed and then neutralized with aqueous sodium hydroxide solution,and then more than 75% riboflavin sodium phosphate is obtained.

Key words: riboflavin sodium phosphate, riboflavin, phosphorus oxychloride, production