Abstract: Objective: To study the hypoglycemic effect of components in mulberry leaves and screen the active hypoglycemic components. Method: Use alloxan-induced diabetic mice as experimental animal, and observe the hypoglycemic effect of components in mulberry leaves. Result: It is found that the polysaccharide and the alkaloid in mulberry leaves can decrease blood glucose, promote synthesis of liver starch and increase hepatic glycogen of the diabetes mice efficiently. But the flavonoid in mulberry leaves has no significant hypoglycemic effect. Conclusion: The polysaccharide and the alkaloid in mulberry leaves have hypoglycemic effect. They can decrease blood glucose, promote synthesis of liver starch and increase hepatic glycogen of the diabetes mice induced by alloxan efficiently.

Key words: components in mulberry leaves, diabetes model, hypoglycemic effect, blood glucose, hepatic glycogen