Abstract: The study was about whether ganoderma luidum reduce the blood lipid s of hyperlipid rats.The object of experiment were male Wastar rats.Then divided i nto four groups(normal diet group,hyperlipid controller group,positive controll e d group and ganoderma luidum group).Normal diet group which were fed with norm al diets.The other three groups which were all fed with hyperlipid diets and ma de them became hyperlipid animal model.Rats were fed with water in normal diet grou p and hyperlipid contrlller group,were fed with pravastain in positive cont rolle d group and were fed with ganoderma luidum in ganoderma luidum group.Total chole sterol(TC),triacylglycerol(TG),high-density-liporotein cholesterol(HDL-C)and ester cholesterol(EC) were measured in 14th and 28th day for all four g roups . The results showed that ganoderma luidum can not only reduce TC and TG v alue in hyperlipid rats significantly (p< 0.05) but also improved HDL-C and le cithin-c holesterol acyltransferase(LCAT)relative significantly(p< 0.001).

Key words: ganoderma luidum, pravastain, blood lipids, LCAT