Abstract: The metabolic syndrome (MS) is a cluster of metabolic abnormalities leading to cardiovascular diseases and type-2 diabetes, which are caused by dietary disorder and unhealthy lifestyle. The prevalence of these diseases which are becoming a global epidemic has been shown to increase with increasing age. NAD+-dependent sirtuin deacetylases can regulate cellular and organism metabolism, and play a distinct role in the regulation of metabolic syndrome. This paper focuses on the elucidation of the regulatory roles of resveratrol on the mediation of metabolic syndrome by SIRT1 and the roles of other SIRT family proteins on metabolic regulation at the molecular level with the purpose of providing scientific references for the development of resveratrol-based functional foods. In addition, sirtuin deacetylases can be as attractive targets for therapeutic intervention of metabolic syndrome and cancer caused by metabolic dysregulation.

Key words: resveratrol, acetylation, metabolic syndrome, SIRT