Advance in Nutrient Composition and Functional Characteristics of Bovine Colostrum

Abstract

Abstract: Colostrum is the milk secreted by cows in the first few days after natural birth. It is rich in lactoferrin, immunoglobulin, antimicrobial peptides and growth factors and other active ingredients. The special nutritional composition of bovine colostrum endows it with a variety of biological activities, such as regulating immunity, improving gastrointestinal health, improving bone health and promoting wound healing. Therefore, bovine colostrum, as a functional food or functional milk ingredient, has attracted extensive attention. In this paper, the nutritional composition, biological function and processing stability of bovine colostrum were described in detail, aiming to provide reference for the development, application and standardized production of bovine colostrum.

Key words: bovine colostrum, nutrients, biological function, processing stability, bovine colostrum products

CLC Number:

TS201.4

MAO Xue-Ying. Advance in Nutrient Composition and Functional Characteristics of Bovine Colostrum[J]. FOOD SCIENCE, 0, (): 0-0.

References

[1] MCGRATH B A, FOX P F, MCSWEENEY P L H, et al. Composition and properties of bovine colostrum: A review[J]. Dairy Science & Technology, 2016,96(2):133-158. DOI: 10.1007/s13594-015-0258-x.
[2] RAJAMANICKAM K. Current and future prospects of colostrum-Indian ethnic food supplement[J]. Journal of Dairy Science and Technology, 2016,5(3): 23-28.
[3] SCAMMELL A W. Production and uses of colostrum[J]. Australian Journal of Dairy Technology, 2001,56(2):74-82.
[4] SANGILD P T, VONDEROHE C, MELENDEZ HEBIB V, et al. Potential benefits of bovine colostrum in pediatric nutrition and health[J]. Nutrients, 2021,13(8):2551. DOI: 10.3390/nu13082551.
[5] KAPLAN M, ARSLAN A, DUMAN H, et al. Production of bovine colostrum for human consumption to improve health[J]. Frontiers in Pharmacology, 2022,12:796824. DOI: 10.3389/fphar.2021.796824.
[6] PLAYFORD R J, WEISER M J. Bovine colostrum: Its constituents and uses[J]. Nutrients, 2021,13(1):265. DOI: 10.3390/nu13010265/.
[7] SANGILD P T, VONDEROHE C, MELENDEZ HEBIB V, et al. Potential benefits of bovine colostrum in pediatric nutrition and health[J]. Nutrients, 2021,13(8):2551. DOI: 10.3390/nu13082551.
[8] ULFMAN L H, LEUSEN J H W, SAVELKOUL H F J, et al. Effects of bovine immunoglobulins on immune function, allergy, and infection[J]. Frontiers in Nutrition, 2018,5. DOI: 10.3389/fnut.2018.00052.
[9] ZHAO X, XU X X, LIU Y, et al. The in vitro protective role of bovine lactoferrin on intestinal epithelial barrier[J]. Molecules, 2019,24(1): 7-13. DOI: 10.3390/molecules24010148.
[10] DONOVAN S M, ODLE J. Growth factors in milk as mediators of infant development[J]. Annual Review of Nutrition, 1994,14:147-167. DOI: 10.1146/annurev.nu.14.070194.001051.
[11] JIA Y, LU Y, WANG X, et al. Mass spectrometry based quantitative and qualitative analyses reveal N-glycan changes of bovine lactoferrin at different stages of lactation[J]. LWT-Food Science and Technology, 2021,147:111626. DOI:10.1016/j.lwt.2021.111626.
[12] JIANG R, L?NNERDAL B. Osteopontin in human milk and infant formula affects infant plasma osteopontin concentrations[J]. Pediatric Research, 2019,85(4):502-505. DOI:10.1038/s41390-018-0271-x.
[13] KUMURA H, MIURA A, SATO E, et al. Susceptibility of bovine osteopontin to chymosin[J]. Journal of Dairy Research, 2004,71(4):500-504. DOI:10.1017/S0022029904000391.
[14] LI M, LI W, KONG F, et al. Metabolomics methods to analyze full spectrum of amino acids in different domains of bovine colostrum and mature milk[J]. European Food Research and Technology, 2020,246(1):213-224. DOI:10.1007/s00217-019-03385-y.
[15] TABATABAIE L, KLOMP L W, BERGER R, et al. L-Serine synthesis in the central nervous system: A review on serine deficiency disorders[J]. Molecular Genetics and Metabolism, 2010,99(3):256-262. DOI:10.1016/j.ymgme.2009.10.012.
[16] LEE Y, STALLCUP M R. Minireview: Protein arginine methylation of nonhistone proteins in transcriptional regulation[J]. Molecular Endocrinology, 2009,23(4):425-433. DOI:10.1210/me.2008-0380.
[17] GHOSH G, ADAMS J A. Phosphorylation mechanism and structure of serine-arginine protein kinases[J]. FEBS Journal, 2011,278(4):587-597. DOI:10.1111/j.1742-4658.2010.07992.x.
[18] MULLER-TIDOW C, WANG W, IDOS G E, et al. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function[J]. Blood, 2001,97(7):2091-2097. DOI:10.1182/blood.V97.7.2091.
[19] EL I A. Taurine regulation of neuroendocrine function[J]. Advances in Experimental Medicine and Biology, 2019,1155:977-985. DOI:10.1007/978-981-13-8023-5_81.
[20] DELPLANQUE B, GIBSON R, KOLETZKO B, et al. Lipid quality in infant nutrition: Current knowledge and future opportunities[J]. Journal of Pediatric Gastroenterology & Nutrition, 2015,61(1):8-17. DOI:10.1097/MPG.0000000000000818.
[21] CONTARINI G, POVOLO M, PELIZZOLA V, et al. Bovine colostrum: changes in lipid constituents in the first 5 days after parturition[J]. Journal of Dairy Science, 2014,97(8):5065-5072. DOI:10.3168/jds.2013-7517.
[22] O'CALLAGHAN T F, O'DONOVAN M, MURPHY J P, et al. Evolution of the bovine milk fatty acid profile-from colostrum to milk five days post parturition[J]. International Dairy Journal, 2020,104:104655. DOI:10.1016/j.idairyj.2020.104655.
[23] WILMS J N, HARE K S, FISCHER-TLUSTOS A J, et al. Fatty acid profile characterization in colostrum, transition milk, and mature milk of primi- and multiparous cows during the first week of lactation[J]. Journal of Dairy Science, 2022,105(3):2612-2630. DOI:10.3168/jds.2021-20880.
[24] CONTARINI G, POVOLO M, PELIZZOLA V, et al. Bovine colostrum: Changes in lipid constituents in the first 5 days after parturition[J]. Journal of Dairy Science, 2014,97(8):5065-5072. DOI:10.3168/jds.2013-7517.
[25] KHALID W, GILL P, ARSHAD M S, et al. Functional behavior of DHA and EPA in the formation of babies brain at different stages of age, and protect from different brain-related diseases[J]. International Journal of Food Properties, 2022,25(1):1021-1044. DOI: 10.1080/10942912.2022.2070642.
[26] JANSSEN C I F, ZERBI V, MUTSAERS M P C, et al. Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL/6J mice[J]. The Journal of Nutritional Biochemistry, 2015,26(1):24-35. DOI: 0.1016/j.jnutbio.2014.08.002.
[27] BASAK S, DUTTAROY A K. Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development[J]. Reproductive Sciences, 2022, 8: 1-15. DOI: 10.1007/s43032-022-00989-w.
[28] SUN J, ZHANG W. Supplementation with dietary omega-3 PUFA mitigates fetal brain inflammation and mitochondrial damage caused by high doses of sodium nitrite in maternal rats[J]. Plos One, 2022,17(3):e266084. DOI: 10.1371/journal.pone.0266084.
[29] SHAMA S, LIU W. Omega-3 fatty acids and gut microbiota: A reciprocal interaction in nonalcoholic fatty liver disease[J]. Digestive Diseases and Sciences, 2020,65(3):906-910. DOI: 10.1007/s10620-020-06117-5.
[30] BIDU C, ESCOULA Q, BELLENGER S, et al. The transplantation of omega 3 PUFA-altered gut microbiota of fat-1 mice to wild-type littermates prevents obesity and associated metabolic disorders [J]. DIABETES, 2019,68(1): 1512-1524. DOI: 10.2337/db19-er01a.
[31] ZALOGA G P. Narrative review of n-3 polyunsaturated fatty acid supplementation upon immune functions, resolution molecules and lipid peroxidation[J]. Nutrients, 2021,13(2):662. DOI: 10.3390/nu13020662.
[32] LI M, LI Q, KANG S, et al. Characterization and comparison of lipids in bovine colostrum and mature milk based on UHPLC-QTOF-MS lipidomics[J]. Food Research International, 2020,136:109490. DOI:10.1016/j.foodres.2020.109490.
[33] CATENZA K F, DONKOR K K. Recent approaches for the quantitative analysis of functional oligosaccharides used in the food industry: A review[J]. Food Chemistry, 2021,355:129416. DOI: 10.1016/j.foodchem.2021.129416.
[34] N. TAO, E.J. DEPETERS, S. FREEMAN, et al. Bovine milk glycome[J]. Journal of Dairy Science, 2008, 91:3768-3778. DOI:10.3168/jds.2008-1305.
[35] SOHANPAL B K, EL-LABANY S, LAHOOTI M, et al. Integrated regulatory responses of fimB to n-acetylneuraminic (sialic) acid and GlcNAc in escherichia coli K-12[J]. Proceedings of the National Academy of Sciences - PNAS, 2004,101(46):16322-16327. DOI:10.1073/pnas.0405821101.
[36] FISCHER A J, MALMUTHUGE N, GUAN L L, et al. Short communication: The effect of heat treatment of bovine colostrum on the concentration of oligosaccharides in colostrum and in the intestine of neonatal male Holstein calves[J]. Journal of Dairy Science, 2018,101(1):401-407. DOI:10.3168/jds.2017-13533.
[37] URASHIMA T, TAUFIK E, FUKUDA K, et al. Recent advances in studies on milk oligosaccharides of cows and other domestic farm animals[J]. Bioscience Biotechnology and Biochemistry, 2013,77(3):455-466. DOI:10.1271/bbb.120810.
[38] FISCHER-TLUSTOS A J, HERTOGS K, VAN NIEKERK J K, et al. Oligosaccharide concentrations in colostrum, transition milk, and mature milk of primi- and multiparous Holstein cows during the first week of lactation[J]. Journal of Dairy Science, 2020,103(4):3683-3695. DOI:10.3168/jds.2019-17357.
[39] NAKAMURA T, KAWASE H, KIMURA K, et al. Concentrations of sialyloligosaccharides in bovine colostrum and milk during the prepartum and early lactation[J]. Journal of Dairy Science, 2003,86(4):1315-1320. DOI:10.3168/jds.S0022-0302(03)73715-1.
[40] MCJARROW P, VAN AMELSFORT-SCHOONBEEK J. Bovine sialyl oligosaccharides: seasonal variations in their concentrations in milk, and a comparison of the colostrums of Jersey and Friesian cows[J]. International Dairy Journal, 2004,14(7):571-579. DOI:10.1016/j.idairyj.2003.11.006.
[41] LI T, GONG H, YUAN Q, et al. Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring[J]. The FASEB Journal, 2020,34(3):4619-4634. DOI:10.1096/fj.201901867RRR.
[42] YUAN Q C, GONG H, DU M, et al. Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring[J]. The FASEB Journal, 2021,35(4). DOI:10.1096/fj.202001974RRR.
[43] SANGILD P T, VONDEROHE C, MELENDEZ HEBIB V, et al. Potential benefits of bovine colostrum in pediatric nutrition and health[J]. Nutrients, 2021,13(8):2551. DOI:10.3390/nu13082551.
[44] JIA W, ZHANG R, ZHU Z, et al. A high-throughput comparative proteomics of milk fat globule membrane reveals breed and lactation stages specific variation in protein abundance and functional differences between milk of saanen dairy goat and holstein bovine[J]. Frontiers in Nutrition, 2021,8. DOI:10.3389/fnut.2021.680683.
[45] CAO X, ZHENG Y, WU S, et al. Characterization and comparison of milk fat globule membrane N-glycoproteomes from human and bovine colostrum and mature milk[J]. Food & Function, 2019,10(8):5046-5058. DOI:10.1039/c9fo00686a.
[46] ZOU X, GUO Z, HUANG J, et al. Human milk fat globules from different stages of lactation: A lipid composition analysis and microstructure characterization[J]. Journal of Agricultural and Food Chemistry, 2012,60(29):7158-7167. DOI:10.1021/jf3013597.
[47] BASTIAN S E, DUNBAR A J, PRIEBE I K, et al. Measurement of betacellulin levels in bovine serum, colostrum and milk[J]. Journal of Endocrinology, 2001,168(1):203-212. DOI:10.1677/joe.0.1680203.
[48] MCGRATH B A, FOX P F, MCSWEENEY P L H, et al. Composition and properties of bovine colostrum: a review[J]. Dairy Science & Technology, 2015,96(2):133-158. DOI:10.1007/s13594-015-0258-x.
[49] RABINOVSKY E D, DRAGHIA-AKLI R. Insulin-like growth factor I plasmid therapy promotes in vivo angiogenesis[J]. Molecular Therapy, 2004,9(1):46-55. DOI:10.1016/j.ymthe.2003.10.003.
[50] MEHRA R, SINGH R, NAYAN V, et al. Nutritional attributes of bovine colostrum components in human health and disease: A comprehensive review[J]. Food Bioscience, 2021,40:100907. DOI:10.1016/j.fbio.2021.100907.
[51] PLAYFORD R J, MARCHBANK T, CALNAN D P, et al. Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice[J]. Gastroenterology, 1995,108(1):92-101. DOI:10.1016/0016-5085(95)90012-8.
[52] PLAYFORD R J, WOODMAN A C, CLARK P, et al. Effect of luminal growth factor preservation on intestinal growth[J]. Lancet, 1993,341(8849):843-848. DOI: 10.1016/0140-6736(93)93057-8.
[53] ISMAIL R I H, AWAD H A, IMAM S S, et al. Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial[J]. Pediatric Research, 2021,90(3):650-656. DOI:10.1038/s41390-020-01344-y.
[54] PATIROGLU T, KONDOLOT M. The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency[J]. Clinical Respiratory Journal, 2013,7(1):21-26. DOI:10.1111/j.1752-699X.2011.00268.x.
[55] RATHE M, DE PIETRI S, WEHNER P S, et al. Bovine colostrum against chemotherapy-induced gastrointestinal toxicity in children with acute lymphoblastic leukemia: A randomized, double-blind, placebo-controlled trial[J]. Journal of Parenteral and Enteral Nutrition, 2020,44(2):337-347. DOI:10.1002/jpen.1528.
[56] SAAD K, ABO-ELELA M G M, EL-BASEER K A A, et al. Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children[J]. Medicine, 2016,95(37):e4560. DOI:10.1097/MD.0000000000004560.
[57] CESARONE M R, BELCARO G, DI RENZO A, et al. Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino[J]. Clinical and Applied Thrombosis-Hemostasis, 2007,13(2):130-136. DOI:10.1177/1076029606295957.
[58] CROOKS C V, WALL C R, CROSS M L, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners[J]. International Journal of Sport Nutrition and Exercise Metabolism, 2006,16(1):47-64. DOI:10.1123/ijsnem.16.1.47.
[59] JENSEN G S, PATEL D, BENSON K F. A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans[J]. Preventive Medicine, 2012,54:S124-S129. DOI:10.1016/j.ypmed.2012.01.004.
[60] CAIRANGZHUOMA, YAMAMOTO M, MURANISHI H, et al. Skimmed, sterilized, and concentrated bovine late colostrum promotes both prevention and recovery from intestinal tissue damage in mice[J]. Journal of Dairy Science, 2013,96(3):1347-1355. DOI:10.3168/jds.2012-5701.
[61] FILIPESCU I E, LEONARDI L, MENCHETTI L, et al. Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice[J]. Plos One, 2018,13(8):e202929. DOI:10.1371/journal.pone.0202929.
[62] KANWAR J R, KANWAR R K, STATHOPOULOS S, et al. Comparative activities of milk components in reversing chronic colitis[J]. Journal of Dairy Science, 2016,99(4):2488-2501. DOI:10.3168/jds.2015-10122.
[63] SPALINGER M R, ATROTT K, BAEBLER K, et al. Administration of the hyper-immune bovine colostrum extract IMM-124E ameliorates experimental murine colitis[J]. Journal of Crohn's and Colitis, 2019,13(6):785-797. DOI:10.1093/ecco-jcc/jjy213.
[64] ST?Y A C F, HEEGAARD P M H, THYMANN T, et al. Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs[J]. Clinical Nutrition, 2014,33(2):322-329. DOI:10.1016/j.clnu.2013.05.013.
[65] KHAN Z, MACDONALD C, WICKS A C, et al. Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study[J]. Alimentary Pharmacology & Therapeutics, 2002,16(11):1917-1922. DOI:10.1046/j.1365-2036.2002.01354.x.
[66] RUBIO A, PIGNEUR B, GARNIER-LENGLINé H, et al. The efficacy of exclusive nutritional therapy in paediatric Crohn’s disease, comparing fractionated oral vs. continuous enteral feeding[J]. Alimentary Pharmacology & Therapeutics, 2011,33(12):1332-1339. DOI:10.1111/j.1365-2036.2011.04662.x.
[67] LI J, XU Y, JIANG J, et al. Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea[J]. Scientific Reports, 2019,9(1). DOI:10.1038/s41598-019-39644-x.
[68] BARAKAT S H, MEHEISSEN M A, OMAR O M, et al. Bovine colostrum in the treatment of acute diarrhea in children: A double-blinded randomized controlled trial[J]. Journal of Tropical Pediatrics, 2019. DOI:10.1093/tropej/fmz029.
[69] HA?ASA M, MACIEJEWSKA D, BA?KIEWICZ-HA?ASA M, et al. Oral supplementation with bovine colostrum decreases intestinal permeability and stool concentrations of zonulin in athletes[J]. Nutrients, 2017,9(4):370. DOI:10.3390/nu9040370.
[70] HA?ASA M, MACIEJEWSKA-MARKIEWICZ D, BA?KIEWICZ-HA?ASA M, et al. Post-delivery milking delay influence on the effect of oral supplementation with bovine colostrum as measured with intestinal permeability test[J]. Medicina, 2020,56(10):495. DOI:10.3390/medicina56100495.
[71] MORRIN S T, MCCARTHY G, KENNEDY D, et al. Immunoglobulin G from bovine milk primes intestinal epithelial cells for increased colonization of bifidobacteria[J]. AMB Express, 2020,10(1): 20-43. DOI: 10.1186/s13568-020-01048-w.
[72] TIAN H, MADDOX I S, FERGUSON L R, et al. Influence of bovine lactoferrin on selected probiotic bacteria and intestinal pathogens[J]. BioMetals, 2010,23(3):593-596. DOI:10.1007/s10534-010-9318-0.
[73] MORRIN S T, LANE J A, MAROTTA M, et al. Bovine colostrum-driven modulation of intestinal epithelial cells for increased commensal colonisation[J]. Applied Microbiology and Biotechnology, 2019,103(6):2745-2758. DOI:10.1007/s00253-019-09642-0.
[74] TAY N, TAN Y C, CHNG K, et al. Effect of human milk formula with bovine colostrum supplementation on bone mineral density in infant cynomolgus macaques[J]. Journal of Developmental Origins of Health and Disease, 2018,9(2):172-181. DOI:10.1017/S2040174417000812.
[75] LEE J R B C, KWON S H, KIM H M, et al. Effect of a growth protein-colostrum fraction on bone development in juvenile rats[J]. Bioscience, Biotechnology, and Biochemistry, 2008,72(1):1-6. DOI:10.1271/bbb.60695.
[76] KYDONAKI E K, FREITAS L, FONSECA B M, et al. Bovine colostrum supplementation improves bone metabolism in an osteoporosis-induced animal model[J]. Nutrients, 2021,13(9):2981. DOI:10.3390/nu13092981.
[77] DUFF W R D, CHILIBECK P D, ROOKE J J, et al. The Effect of bovine colostrum supplementation in older adults during resistance training[J]. International Journal of Sport Nutrition and Exercise Metabolism, 2014,24(3):276-285. DOI:10.1123/ijsnem.2013-0182.
[78] MARTIN-ARAGON S, BERMEJO-BESCóS P, BENEDí J, et al. A neuroprotective bovine colostrum attenuates apoptosis in dexamethasone-treated MC3T3-E1 osteoblastic cells[J]. International Journal of Molecular Sciences, 2021,22(19):10195. DOI:10.3390/ijms221910195.
[79] MUSSANO F, BARTORELLI C A, BROSSA A, et al. Presence of osteoinductive factors in bovine colostrum[J]. Bioscience Biotechnology and Biochemistry, 2014,78(4):662-671. DOI:10.1080/09168451.2014.896733.
[80] DU M, XU W, YI H, et al. Protective effects of bovine colostrum acid proteins on bone loss of ovariectomized rats and the ingredients identification[J]. Molecular Nutrition & Food Research, 2011,55(2):220-228. DOI:10.1002/mnfr.200900593.
[81] YUN B, MABURUTSE B E, KANG M, et al. Short communication: Dietary bovine milk–derived exosomes improve bone health in an osteoporosis-induced mouse model[J]. Journal of Dairy Science, 2020,103(9):7752-7760. DOI:10.3168/jds.2019-17501.
[82] ANTONIO J, SANDERS M S, VAN GAMMEREN D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women[J]. Nutrition, 2001,17(3):243-247. DOI:10.1016/S0899-9007(00)00552-9.
[83] KOTSIS Y, MIKELLIDI A, ARESTI C, et al. A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates inflammatory indices following a Loughborough Intermittent Shuttle Test in soccer players[J]. European Journal of Nutrition, 2018,57(3):1181-1195. DOI:10.1007/s00394-017-1401-7.
[84] SHING C M, JENKINS D G, STEVENSON L, et al. The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists[J]. British Journal of Sports Medicine, 2006,40(9):797-801. DOI:10.1136/bjsm.2006.027946.
[85] COOMBES J S, CONACHER M, AUSTEN S K, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists[J]. Medicine and Science in Sports and Exercise, 2002,34(7):1184-1188. DOI:10.1097/00005768-200207000-00020.
[86] DAVISON G. The use of bovine colostrum in sport and exercise[J]. Nutrients, 2021,13(6):1789. DOI:10.3390/nu13061789.
[87] KIM J H, JUNG W S, CHOI N, et al. Health-promoting effects of bovine colostrum in type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones[J]. The Journal of Nutritional Biochemistry, 2009,20(4):298-303. DOI:10.1016/j.jnutbio.2008.04.002.
[88] HWANG K, HWANG Y, HA W, et al. Oral administration of insulin-like growth factor-I from colostral whey reduces blood glucose in streptozotocin-induced diabetic mice[J]. British Journal of Nutrition, 2012,108(1):39-45. DOI:10.1017/S0007114511005198.
[89] MIZRAHI M, SHABAT Y, BEN Y A, et al. Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH[J]. Journal of Inflammation Research, 2012,5:141-150. DOI:10.2147/JIR.S35227.
[90] KOVACS D, CARDINALI G, ASPITE N, et al. Bovine colostrum promotes growth and migration of the human keratinocyte HaCaT cell line[J]. Growth Factors, 2009,27(6):448-455. DOI:10.3109/08977190903211077.
[91] KOVACS D, MARESCA V, FLORI E, et al. Bovine colostrum induces the differentiation of human primary keratinocytes[J]. The FASEB Journal, 2020,34(5):6302-6321. DOI:10.1096/fj.201900103RRR.
[92] KSHIRSAGAR A Y. A comparative study of colostrum dressing versus conventional dressing in deep wounds[J]. Journal of Clinical and Diagnostic Research, 2015. DOI:10.7860/JCDR/2015/12004.5739.
[93] LICHAN E, KUMMER A, LOSSO J N, et al. Stability of bovine immunoglobulins to thermal-treatment and processing[J]. Food Research International, 1995,28(1):9-16. DOI:10.1016/0963-9969(95)93325-O.
[94] STABEL J R, HURD S, CALVENTE L, et al. Destruction of mycobacterium paratuberculosis, salmonella spp., and mycoplasma spp. in raw milk by a commercial on-farm high-temperature, short-time pasteurizer[J]. Journal of Dairy Science, 2004,87(7):2177-2183. DOI:10.3168/jds.S0022-0302(04)70038-7.
[95] MEYLAN M, RINGS D M, SHULAW W P, et al. Survival of Mycobacterium paratuberculosis and preservation of immunoglobulin G in bovine colostrum under experimental conditions simulating pasteurization[J]. American Journal of Veterinary Research, 1996,57(11):1580-1585. DOI: 10.3354/dao027157.
[96] NGUYEN D N, CURRIE A J, REN S, et al. Heat treatment and irradiation reduce anti-bacterial and immune-modulatory properties of bovine colostrum[J]. Journal of Functional Foods, 2019,57:182-189. DOI:10.1016/j.jff.2019.04.012.
[97] GOSCH T, APPRICH S, KNEIFEL W, et al. A combination of microfiltration and high pressure treatment for the elimination of bacteria in bovine colostrum[J]. International Dairy Journal, 2014,34(1):41-46. DOI:10.1016/j.idairyj.2013.06.014.
[98] BORAD S G, SINGH A K, KAPILA S, et al. Influence of unit operations on immunoglobulins and thermal stability of colostrum fractions[J]. International Dairy Journal, 2019,93:85-91. DOI:10.1016/j.idairyj.2019.02.007.
[99] OLLIKAINEN P, MUURONEN K, TIKANM?KI R. Effect of pasteurization on the distribution of bovine milk transforming growth factor-β2 in casein and whey fractions during micro- and ultrafiltration processes[J]. International Dairy Journal, 2012,26(2):141-146. DOI:10.1016/j.idairyj.2012.04.004.
[100] KUMAR M, UPRIT S. Bovine colostrum: Neonate to nutraceuticals[J]. Research Journal of Animal Husbandry & Dairy ence, 2015, 5(1): 23-19.
[101] SOTUDEH S, RABBANI KHORASGANI M, ETEMADIFAR Z, et al. Effects of spray-drying, freeze-drying and pasteurization on microbiological quality and igg level of bovine colostrum[J]. Journal of Food Quality and Hazards Conrol, 2018,5(2):54-60. DOI: 10.29252/jfqhc.5.2.5.
[102] STY A C, SANGILD P T, SKOVGAARD K, et al. Spray dried, pasteurised bovine colostrum protects against gut dysfunction and inflammation in preterm pigs[J]. Journal of Pediatric Gastroenterology and Nutrition, 2016,63(2):280-287. DOI:10.1097/MPG.0000000000001056 .
[103] ELFSTRAND L, LINDMARK-MANSSON H, PAULSSON M, et al. Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing[J]. International Dairy Journal, 2002, 879-887. DOI: 10.1016/S0958-6946(02)00089-4.
[104] DE OLIVEIRA A H, MATA M E R M, FORTES M, et al. Influence of spray drying conditions on the properties of whole goat milk[J]. Drying Technology, 2021,39(6):726-737. DOI: 10.1080/07373937.2020.1714647.
[105] BARREIRO R, REGAL P, DIAZ-BAO M, et al. Analysis of naturally occurring steroid hormones in infant formulas by HPLC-MS/MS and contribution to dietary intake[J]. Foods (Basel, Switzerland), 2015,4(4):605-621. DOI: 10.3390/foods4040605.
[106] UCHIDA K, YAMAGUCKI H, KAWASAKI M, et al. Bovine late colostrum (colostrum 6 or 7 days after parturition) supplement reduces symptoms of upper respiratory tract infection in infant[J]. Journal of Japanese Society of Clinical Nutrition, 2010, 31:122-127.
[107] LI Y, JUHL S M, YE X, et al. A stepwise, pilot study of bovine colostrum to supplement the first enteral feeding in preterm infants (precolos): Study protocol and initial results[J]. Frontiers in Pediatrics, 2017,5. DOI: 10.3389/fped.2017.00042.
[108] PATEL K, RANA R. Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study[J]. Indian Journal of Pediatrics, 2006,73(7):585-591. DOI: 10.1007/BF02759923.
[109] JONES A W, CAMERON S J S, THATCHER R, et al. Effects of bovine colostrum supplementation on upper respiratory illness in active males[J]. Brain, Behavior, and Immunity, 2014,39:194-203. DOI: 10.1016/j.bbi.2013.10.032.
[110] SHING C M, PEAKE J, SUZUKI K, et al. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists[J]. Journal of Applied Physiology, 2007,102(3):1113-1122. DOI: 10.1152/japplphysiol.00553.2006.
[111] ESLAMIAN G, ARDEHALI S H, BAGHESTANI A R, et al. Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study[J]. Nutrition, 2019,60:106-111. DOI: 10.1016/j.nut.2018.10.013.
[112] GUBERTI M, BOTTI S, CAPUZZO M T, et al. Bovine colostrum applications in sick and healthy people: A systematic review[J]. Nutrients, 2021,13(7):2194. DOI: 10.3390/nu13072194.