FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (1 ): 158-161.doi: 10.7506/spkx1002-6630-201101038

• Bioengineering • Previous Articles     Next Articles

Batch Fermentation Kinetics for Glutathione Production by Saccharomyces cerevisiae

ZHENG Li-xue,WANG Li-mei,MEI Yan-zhen,QI Bin*   

  1. College of Biology and Food Engineering, Changshu Institute of Technology, Changshu 215500, China
  • Received:2010-03-25 Revised:2010-12-15 Online:2011-01-15 Published:2010-12-28
  • Contact: QI Bin* E-mail:qibin65@126.com

Abstract:

A kinetic model of glutathione production by batch fermentation with Saccharomyces cerevisiae Y518 was studied by using malt sprout extract as the carbon source in a 7.5 L fermenter. The kinetic models for cell growth, glutathione production and substrate consumption were developed respectively by Logistic equation, Luedeking-Piret equation and materials balance equation through optimal parameter estimation and nonlinear fitting. The optimal set of parameters was estimated by fitting the model to experimental data. The results predicted by the model were in good agreement with the experimental observations and showed that the models could provide a reasonable description for the batch fermentation of glutathione.

Key words: glutathione, malt sprout extract, Saccharomyces cerevisiae, fermentation kinetic model, fitting

CLC Number: