Abstract:

Objectives: To investigate anti-coagulation and anti-thrombosis effects of n-butanol extract from Oenanthe aquatic. Methods: The effect of n-butanol extract from Oenanthe aquatic on coagulation time and bleeding time of mouse tails was investigated using glass coverslip, capillary and cutting tail methods. Meanwhile, the effect of n-butanol extract from Oenanthe aquatic on thrombosis and thrombosis of arterio-venous bypass in rabbits was studied using Chandle and arterio-venous bypass methods. In addition, the effect of n-butanol extract from Oenanthe aquatic on platelet adhesion function in rabbits was also studied using Wright method. Results: n-butanol extract from Oenanthe aquatic at the doses of 500 mg/(kg bw·d)and 250 mg/(kg bw·d) significantly prolonged coagulation time and bleeding time in mice. When the dose was 280 or 140 mg/(kg bw·d), thrombosis and thrombosis of arterio-venous bypass in rabbits were significantly inhibited and a significant inhibitory effect on platelet adhesion function in rabbits was observed. Conclusion: n-butanol extract from Oenanthe aquatic has anti-coagulation and antithrombosis effects.

Key words: n-butanol extract from Oenanthe aquatic, coagulation time, bleeding time, thrombosis, platelet adhesion