食品科学 ›› 2005, Vol. 26 ›› Issue (9): 487-489.

• 营养卫生 • 上一篇    下一篇

葫芦素B对急性酒精性黄疸保护作用的研究

 魏凤辉, 曲红光, 王红, 杨世杰, 昌友权   

  1. 吉林大学临床医学,白城医学高等专科学校,吉林工程技术师范学院生物与食品工程系,吉林大学基础医学院药理教研室
  • 出版日期:2005-09-15 发布日期:2011-09-20

Protective Effects of SMVE on the Acute Alcohol Liver Injured Jaundice

 WEI  Feng-Hui, QU  Hong-Guang, WANG  Hong, YANG  Shi-Jie, CHANG  You-Quan   

  1. 1.Baicheng College of Hight Mediune; 2.Department of Biology and Food Engineering, Jilin Normal Institde of Engineering and Technology; 3.Department of Phamacology, School of Basic Medical Science, Jilin University; 4.School of Basic Medical Science , Jilin University
  • Online:2005-09-15 Published:2011-09-20

摘要: 目的:研究葫芦素B对酒精所致的黄疸的保护作用。方法:采用SMVE灌胃预防给药7d,然后一次酒精灌胃,眶静脉取血测GPT、TP含量和肝组织匀装MDA含量,采用HE染色和PSA染色法观察葫芦素B对肝细胞形态学的变化的影响。结果:葫芦素B可降低酒精灌胃小鼠血清TB含量,降低肝组织匀浆中MDA含量,降低肝细胞的水肿程度。结论:葫芦素B对酒精灌胃小鼠引起的黄疸具有保护作用,此作用与其增强机体清除自由基的能力,降低肝细胞的水肿程度有关。

关键词: 葫芦素B, 酒精, 黄疸, 脂质过氧化

Abstract: objective to investigate the protective effects of Cucurbitacin B on acute alcohol injured jaundice model. methods after 7 days intragastric administration of alcohol. The changes of the content of GPT and TB in the serum were monitored, and the volume of MDA in the live homogenate was also monitored. We also dye the liver tissue with HE and PSA, then we can see the change of hepatocyte. results Cucurbitacin B can reduce the quantity of TB and MDA in the acute alcohol injured mice. conclusion Cucurbitacin B has protective effects on acute alcohol injured jaundice.

Key words: Cucurbitacin B, alcohol, jaundice, liver injury, lipid peroxidation