食品科学 ›› 2008, Vol. 29 ›› Issue (10): 546-548.

• 营养卫生 • 上一篇    下一篇

白首乌多糖的免疫活性研究

 高丽君, 王建华, 崔建华, 王汉忠   

  1. 泰山医学院生物科学系; 山东农业大学农学院; 泰山医学院化学与化学工程学院;
  • 出版日期:2008-10-15 发布日期:2011-12-08

Study on Immune Activity of Radix Cynanchi Bungei Polysaccharides

 GAO  Li-Jun, WANG  Jian-Hua, CUI  Jian-Hua, WANG  Han-Zhong   

  1. 1.Department of Biological Sciences,Taishan Medical University,Taian 271016,China; 2.College of Agronomy,Shandong Agricultural University,Taian 271018,China; 3.School of Chemistry and Chemical Engineering,Taishan Medical University,Taian 271016,China
  • Online:2008-10-15 Published:2011-12-08

摘要: 目的:研究了白首乌多糖(RCBPs)体外对兔T淋巴细胞转化及体内对正常小鼠免疫功能的影响。方法:将RCBPs分为2、4、6g/L三个剂量组,分别加入含有兔血的营养瓶内,通过观察T淋巴细胞的转化情况,研究多糖体外免疫功能状况;另将RCBPs分为高、中、低三个剂量组(150、100、50mg/kg·d),连续给小鼠灌胃7d,并进行小鼠体内免疫功能测试。结果:RCBPs各剂量组,均能极显著地(p<0.01)促进PHA诱导的家兔T淋巴细胞在体外的增殖能力;RCBPs能提高小鼠的胸腺和脾脏指数、巨噬细胞的吞噬功能、增强小鼠迟发型超敏反应、加速碳粒的清除。结论:白首乌多糖具有免疫调节活性。

关键词: 白首乌, 多糖, 免疫活性

Abstract: Objective:To study the effects of Radix Cynanchi Bungei polysaccharides (RCBPs) on transformation of T lymphocytes of rabbit phtohemagg luti and immune function in mice. Methods: Three doses of RCBPs (2,4 and 6 g/L) were respectively put into bottle with Pgytohemagg lutinin (PHA) and rabbit blood. The effect of RCBPs on immunity in vitro was studied by observing transformation of T lymphocytes; The dosages of RCBPs (150,100,50 mg/kg·d) were given to mice orally for seven days.The effects on immune function in the mice were investigated. Results: Three doses of RCBPs can significantly promote (p<0.01) the ability of rabbit T lymphocytes. The RCBPs can improve the Thymus and spleen indexes,the celiac macrophage ability of engulfing CRBC,the delayed type hypersensitivity ability and the macrophage-engulfing carbon granula ability. Conclusion: The RCBPs has certain activity of immune regulation.

Key words: Radix Cynanchi bungei, polysaccharides, immune activity