南瓜皮粗多糖对小鼠抗疲劳功效研究

doi:10.7506/spkx1002-6630-201413050

食品科学

南瓜皮粗多糖对小鼠抗疲劳功效研究

王强，龙洁，李贵节，王存

1.重庆第二师范学院生物与化学工程系，重庆 400067；2.重庆第二师范学院教务处，重庆 400067

出版日期:2014-07-15 发布日期:2014-07-18

Anti-fatigue Effect of Polysaccharides Extracted from Pumpkin Peel in Aged Mice

WANG Qiang, LONG Jie, LI Gui-jie, WANG Cun

1. Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China;
2. Office of Academic Administration, Chongqing University of Education, Chongqing 400067, China

Online:2014-07-15 Published:2014-07-18

摘要/Abstract

摘要：

研究南瓜皮粗多糖（pumpkin peel polysaccharides，PPPs）对D-半乳糖诱导衰老模型小鼠的游泳耐力和相关生理指标的影响。将小鼠分为正常对照组、衰老模型对照组、PPPs低剂量组（125 mg/（kg·d））、中剂量组（250 mg/（kg·d））和高剂量组（500 mg/（kg·d））。通过腹腔注射100 mg/（kg·d）D-半乳糖，连续60 d建立衰老模型；灌胃给药20 d后，考察其对力竭游泳时间以及血尿素氮、血乳酸、肝糖原、肌糖原、丙二醛含量和超氧化物歧化酶及血乳酸脱氢酶活性的影响。结果表明：PPPs能延长小鼠力竭游泳时间、增加小鼠游泳耐力、降低血尿素氮、血乳酸、丙二醛含量、增加糖原储备量和超氧化物歧化酶及血乳酸脱氢酶活性，说明PPPs对小鼠具有很好的抗疲劳作用。

关键词: 南瓜皮多糖, D-半乳糖, 抗疲劳, 力竭游泳时间

Abstract:

The effect of polysaccharides extracted from pumpkin peel (PPPs) on the exhaustive swimming time and related
physiological indexes in mouse models of aging induced by D-galactose was investigated. Mice were randomly divided into
normal control group, aged model group, low-dose PPPs group (125 mg/(kg·d)), middle-dose PPPs group (250 mg/(kg·d)),
and high-dose PPPs group (500 mg/(kg·d)). The aging model was induced by D-galactose at a dose of 100 mg/(kg·d) for
60 consecutive days. The mice in three PPPs groups were administered with PPPs by gavage from day 41 onward for the
next 20 days, while those in the normal control and aged model groups with distilled water. After the last administration,
exhaustive swimming time and the contents of blood urea nitrogen (BUN), blood lactic acid (BLA), hepatic glycogen (HG),
muscle glycogen (MG), MDA, SOD and lactic dehydrogenase (LDH) were determined. The results showed that PPPs could
extend the exhaustive swimming time, decrease the contents of BUN, BLA and MDA, and obviously increase the reservation
of HG, MG, SOD and LDH. In conclusion, PPPs have an excellent anti-fatigue effect in mice.

Key words: polysaccharides extracted from pumpkin peel, D-galactose, anti-fatigue effect, exhaustive swimming time

王强，龙洁，李贵节，王存. 南瓜皮粗多糖对小鼠抗疲劳功效研究[J]. 食品科学, doi: 10.7506/spkx1002-6630-201413050.

WANG Qiang, LONG Jie, LI Gui-jie, WANG Cun. Anti-fatigue Effect of Polysaccharides Extracted from Pumpkin Peel in Aged Mice[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201413050.

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南瓜皮粗多糖对小鼠抗疲劳功效研究

Anti-fatigue Effect of Polysaccharides Extracted from Pumpkin Peel in Aged Mice

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