Abstract:

Objective: To investigate the effects of resveratrol (Res) on learning, memory and brain antioxidant capacitiesin D-galactose-induced aging mice. Methods: Fifty ICR mice were randomly divided into five groups, designated as normalcontrol, model, resveratrol low-dose, moderate-dose and high-dose groups. The normal control group was given normalsaline by gavage, and all other groups were given D-galactose solution by neck back subcutaneous injection at the dailydose of 120 mg/(kg·d) for 8 consecutive weeks. At the same time, Res-treated mice were administered Res by gavageat the daily doses of 25, 50 and 100 mg/(kg·d) body weight per day, respectively. The learning and memory abilities ofmice were determined by Morris water maze test. Superoxide dismutase (SOD), total antioxidant capacity (T-AOC) andmalondialdehyde (MDA) in the brain of mice were determined at the end of 12 h of fasting after the last administration. Results:Res could reduce the time mice spent on finding platform (P ＜ 0.01), improve the swimming speed (P ＜ 0.01) and the number oftimes mice crossed the platform (P ＜ 0.01) in Morris water maze test, increase SOD (P ＜ 0.01) and T-AOC activities (P ＜ 0.05)and decrease the content of MDA (P ＜ 0.01) in brain tissue. Conclusion: Res can ameliorate the degeneration of learning andmemory abilities in D-galactose-induced aging mice, improve brain antioxidant abilities and thus delay brain aging.

Key words: resveratrol, D-galactose, learning and memory abilities, antioxidation