Optimization of Medium Constituents for Cordycepin Production by Cordyceps militaris in Solid State Fermentation

doi:10.7506/spkx1002-6630-201321051

Abstract

Abstract:

The medium constituents for producing celium cordycepin by Cordyceps militaris in solid state fermentation
were optimized. The effects of medium matrix, liquid/solid ratio, carbon sources, nitrogen sources and metal ions in nutrient
solution on the yield of cordycepin were studied by single factor and orthogonal array design methods. Results suggested
that the optimal medium constituents were soybean meal/wheat bran ratio of 4:1, liquid/solid ratio of 39:30, glucose
concentration of 10 g/L, beef extract concentration of 2 g/L and manganese sulfate of 0.3 g/L in nutrient solution. Under
these conditions the yield of cordycepin was 5499.12 μg/g.

Key words: cordycepin, Cordyceps militaris, solid state fermentation, medium

CLC Number:

TS264.2

GU Dong-yan，YIN Yong-qi，YANG Run-qiang，GU Zhen-xin*. Optimization of Medium Constituents for Cordycepin Production by Cordyceps militaris in Solid State Fermentation[J]. FOOD SCIENCE, 2013, 34(21): 254-258.

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