食品科学 ›› 2009, Vol. 30 ›› Issue (23 ): 436-438.doi: 10.7506/spkx1002-6300-200923098

• 营养卫生 • 上一篇    下一篇

植物乳杆菌Lactobacillus plantarum GUO安全性研究

郭 翔1,艾连中2,吴 艳2,3,张 灏1,陈 卫1,郭本恒2,*   

  1. 1.江南大学食品学院 2.光明乳业股份有限公司技术中心 3.上海交通大学农业与生物学院
  • 收稿日期:2009-08-20 出版日期:2009-12-01 发布日期:2010-12-29
  • 通讯作者: 郭本恒 E-mail:awy7677@hotmail.com
  • 基金资助:

    上海市科技人才计划项目(08QB14003);上海市博士后基金项目(08R214207)

Mutagenicity and Virulence Evaluation of Lactobacillus plantarum GUO

GUO Xiang1,AI Lian-zhong2,WU Yan2,3,ZHANG Hao1,CHEN Wei1,GUO Ben-heng2,*   

  1. 1. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China;2. Technical Center, Bright Dairy Co. Ltd.,
    Shanghai 200436, China;3. School of Agriculture and Biology, Shanghai Jiao Tong University,Shanghai 200240, China
  • Received:2009-08-20 Online:2009-12-01 Published:2010-12-29
  • Contact: GUO Ben-heng E-mail:awy7677@hotmail.com

摘要:

对实验室筛选得到一株具有降胆固醇作用的植物乳杆菌GUO(Lactobacillus plantarum GUO)进行致突变性试验和毒力试验,以测定该菌株的食用安全性。致突变性试验结果表明:在加大鼠肝微粒体酶S9 和不添加的条件下,与自发回变菌落数的差异皆不显著,且与剂量效应无关,而阳性对照的回变菌落数均显著增加(P < 0.05),说明Lactobacillus plantarum GUO 无致突变作用;毒力试验结果表明:Lactobacillus plantarum GUO 低、高浓度培养液与各自对照组相比,对小鼠体重增加的影响无统计学意义(P > 0.05),且受试小鼠无毒力性反应或死亡。

关键词: 植物乳杆菌, 致突变性, 毒力, 安全性

Abstract:

Mutagenicity and virulence of Lactobacillus plantarum GUO, a cholesterol-reducing bacterium, were evaluated by conducting Ames test and animal test, respectively. There were no statistical significances of revertant colony number between Lactobacillus plantarum GUO treated groups and the control group, with or without S9 presence, and in a group between different Lactobacillus plantarum GUO dosages, while significance were found between control and positive control group in the Ames test (P < 0.05). This indicated that Lactobacillus plantarum GUO was probably of no mutagenicity. No tested SD rats had virulence reaction or died, and no statistically significant body weight changing was observed.

Key words: Lactobacillus plantarum GUO, mutagenicity, virulence, safety

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