富硒轮梗霉与奶醋对小鼠降血脂和抗氧化作用的影响

doi:10.7506/spkx1002-6630-200917075

食品科学 ›› 2009, Vol. 30 ›› Issue (17 ): 319-323.doi: 10.7506/spkx1002-6630-200917075

富硒轮梗霉与奶醋对小鼠降血脂和抗氧化作用的影响

管娴月¹，戴传超^1,*，徐玉芬¹，朱明²，张凯¹

1.南京师范大学生命科学学院，江苏省生物多样性与生物技术重点实验室 2.淮海工学院江苏省海洋生物技术重点建设实验室

收稿日期:2009-05-21 出版日期:2009-09-01 发布日期:2014-04-14
通讯作者: 戴传超1,*， E-mail:daichuanchao@njnu.edu.cn
基金资助:
“十一五”国家科技支撑计划项目(2006BAD27B09)；江苏省海洋生物技术重点建设实验室开放项目(2007HS012)

Hypolipidemic and Antioxidation Effects of Selenium-enriched Mycelia of Diasporangium sp. or/and Milk Vinegar on Mice

GUAN Xian-yue1，DAI Chuan-chao1,*，XU Yu-fen1，ZHU Ming2，ZHANG Kai1

1. Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing
210046, China；2. Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology, Lianyungang 222005, China

Received:2009-05-21 Online:2009-09-01 Published:2014-04-14
Contact: DAI Chuan-chao1,*， E-mail:daichuanchao@njnu.edu.cn

摘要/Abstract

摘要：

84 只昆明系雄性小鼠，随机均分为7 组：普通对照组、高脂对照组、亚硒酸钠组、轮梗霉组、富硒轮梗霉组、奶醋组、奶醋+ 富硒轮梗霉组，30d 后测定小鼠空腹体重量、脏器指数、血脂和抗氧化力指标水平、组织硒含量以及肝脏脂肪酸含量。结果表明：富硒轮梗霉能显著降低高脂血症小鼠的TC、TG 和LDL-C，升高HDL-C，降低高脂血症小鼠MDA 的水平，提高SOD、GSH-Px 活性。富硒轮梗霉与奶醋复配对小鼠各检测指标的影响优于富硒轮梗霉组。亚硒酸钠组中组织硒含量显著高于对照组但低于富硒轮梗霉和奶醋富硒轮梗霉组。富硒轮梗霉组的花生四烯酸含量显著提高，含量为11.94%。富硒轮梗霉能显著提高机体降血脂和抗氧化能力，与奶醋复配后效果仍优于其他组别。

关键词: 硒, 奶醋, 轮梗霉, 降血脂, 抗氧化

Abstract:

For the purpose of providing theoretical references for the development of healthcare foods which can offer cardiovascular protection, the hypolipidemic and antioxidation effects of selenium-enriched mycelia of Diasporangium sp., milk vinegar and selenium-enriched mycelia of Diasporangium sp. plus milk vinegar on mice were investigated. Eighty-four male Kunming mice were randomly divided into control, high fat model, sodium selenite, Diasporangium sp., selenium-enriched Diasporangium sp., milk vinegar and milk vinegar plus selenium-enriched Diasporangium sp. groups. After 30 d feeding stage, the changes in serum lipid, viscera index, antioxidation system level, Se content and fatty acids of liver and body weight were observed. Selenium-enriched mycelia of Diasporangium sp. could significantly reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) and increase high-density lipoprotein cholesterol (HDL-C). The activities of serum surperoxide dismutase (SOD) and lutathione peroixdase (GSH-Px) in the selenium-enriched Diasporangium sp. group were significantly higher than those in the other groups, and the malondialdehyde (MDA) level was significantly lower. All the measured indexes of mice fed selenium-enriched Diasporangium sp. plus milk vinegar were better than those of mice only fed selenium-enriched Diasporangium sp.. The Se content of the sodium selenite group was significantly higher than that of the control group, but lower than those of the selenium-enriched Diasporangium sp. and the milk vinegar plus selenium-enriched Diasporangium sp. groups. The content of arachidonic acid of the selenium-enriched Diasporangium sp. group reached 11.94%, which was significantly increased. The results showed that selenium-enriched Diasporangium sp. is able to significantly reduce blood lipid and enhance antioxidation function in mice and the combination of it and milk vinegar has much better effects than those of other groups.

Key words: selenium, milk vinegar, Diasporangium sp., blood lipid reduction, antioxidation

中图分类号:

Q949.32

管娴月1，戴传超1,*，徐玉芬1，朱明2，张凯1. 富硒轮梗霉与奶醋对小鼠降血脂和抗氧化作用的影响[J]. 食品科学, 2009, 30(17 ): 319-323.

GUAN Xian-yue1，DAI Chuan-chao1,*，XU Yu-fen1，ZHU Ming2，ZHANG Kai1. Hypolipidemic and Antioxidation Effects of Selenium-enriched Mycelia of Diasporangium sp. or/and Milk Vinegar on Mice[J]. FOOD SCIENCE, 2009, 30(17 ): 319-323.

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富硒轮梗霉与奶醋对小鼠降血脂和抗氧化作用的影响

Hypolipidemic and Antioxidation Effects of Selenium-enriched Mycelia of Diasporangium sp. or/and Milk Vinegar on Mice

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