羊肚菌多糖PMEP-1对大鼠肠道内短链脂肪酸的影响

doi:10.7506/spkx1002-6630-201019081

食品科学 ›› 2010, Vol. 31 ›› Issue (19): 367-371.doi: 10.7506/spkx1002-6630-201019081

羊肚菌多糖PMEP-1对大鼠肠道内短链脂肪酸的影响

明建^1,2，吴素蕊³，曾凯芳^1,2，桂明英³，陈宗道^1,2，赵国华^1,2,*

1.西南大学食品科学学院
2.重庆市特色食品工程技术研究中心 3.昆明食用菌研究所

收稿日期:2010-05-11 修回日期:2010-09-11 出版日期:2010-10-15 发布日期:2010-12-29
通讯作者: 赵国华 E-mail:zhaoguohua1971@163.com
基金资助:
中央高校基本科研业务费专项资金项目(XDJK2009C044)；西南大学博士基金项目(SWU109005)；
云南省省校省院科技合作支持项目(2005YX24)

Effect of a Polysaccharide Fraction from Fruit Bodies of Morchella esculenta (L.) Pers on Short-chain Fatty Acids in Intestinal Tract of Rats

MING Jian1,2，WU Su-rui3，ZENG Kai-fang1,2，GUI Ming-ying3，CHEN Zong-dao1,2，ZHAO Guo-hua1,2,*

1. College of Food Science, Southwest University, Chongqing 400715, China；2. Chongqing Special Food Programme and Technology
Research Center, Chongqing 400715, China；3. Kunming Research Institute of Edible Mushroom, Kunming 650223, China

Received:2010-05-11 Revised:2010-09-11 Online:2010-10-15 Published:2010-12-29
Contact: ZHAO Guo-hua1 E-mail:zhaoguohua1971@163.com

摘要/Abstract

摘要：

研究羊肚菌多糖PMEP-1 对大鼠肠道内短链脂肪酸的影响。以SD 大鼠为实验模型，进行分组喂养，分别灌胃高剂量(400mg/(kg bw·d))、中等剂量(200mg/(kg bw·d))、低剂量(mg/(kg bw·d))的羊肚菌多糖PMEP-1，为期4 周，定期收集大鼠粪便样。粪便处理后通过气相色谱法测定大鼠肠道内的短链脂肪酸含量。结果表明：羊肚菌多糖PMEP-1 对于大鼠肠道内乙酸、丙酸、异丁酸、丁酸、戊酸、己酸的产生有较大影响，而对于庚酸和异戊酸没有明显作用；不同的灌胃剂量对大鼠肠道短链脂肪酸的影响有较大差异，以中等剂量和低剂量多糖对短链脂肪酸的产生影响明显，各剂量组大鼠肠道内短链脂肪酸的含量在第7～14 天时最多。

关键词: 羊肚菌, 多糖, 短链脂肪酸, 大鼠

Abstract:

In this study, the effect of a polysaccharide fraction from fruit bodies of Morchella esculenta (L.) Pers, named PMEP-1 on short-chain fatty acids in the intestinal tract of rats was investigated. SD rats were orally administered PMEP-1 at high dosage (400 mg/kg bw·d), medium dosage (200 mg/kg bw·d) and low dosage (100 mg/kg bw·d) for a period of four weeks. Rat feces were collected periodically during the trial. Short-chain fatty acids in intestinal tract of rats were determined by gas chromatography. The results indicated that PMEP-1 had an obvious effect on the production of acetic acid, propionic acid, isobutyric acid, butyric acid, valeric acid and caproic acid, but had no obvious effect on the production of heptanoic acid and isovaleric acid. PMEP-1 at various dosages exhibited considerably different effects on short-chain fatty acids. An obvious effect of medium and low dosages of PMEP-1 on short-chain fatty acids was observed. The highest productivity of short-chain fatty acids in intestinal tract of rats in each dose group appeared at 7 － 14 days.

Key words: Morchella esulenta (L.) Pers., polysaccharide, short-chain fatty acids, rat

中图分类号:

R972.6

明建1,2，吴素蕊3，曾凯芳1,2，桂明英3，陈宗道1,2，赵国华1,2,*. 羊肚菌多糖PMEP-1对大鼠肠道内短链脂肪酸的影响[J]. 食品科学, 2010, 31(19): 367-371.

MING Jian1,2，WU Su-rui3，ZENG Kai-fang1,2，GUI Ming-ying3，CHEN Zong-dao1,2，ZHAO Guo-hua1,2,*. Effect of a Polysaccharide Fraction from Fruit Bodies of Morchella esculenta (L.) Pers on Short-chain Fatty Acids in Intestinal Tract of Rats[J]. FOOD SCIENCE, 2010, 31(19): 367-371.

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羊肚菌多糖PMEP-1对大鼠肠道内短链脂肪酸的影响

Effect of a Polysaccharide Fraction from Fruit Bodies of Morchella esculenta (L.) Pers on Short-chain Fatty Acids in Intestinal Tract of Rats

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