食品科学 ›› 2012, Vol. 33 ›› Issue (1): 1-15.doi: 10.7506/spkx1002-6630-201201001
• 专家约稿 • 下一篇
庞广昌,陈庆森,胡志和
收稿日期:
2011-10-31
修回日期:
2011-12-27
出版日期:
2012-01-15
发布日期:
2012-01-12
通讯作者:
庞广昌
E-mail:pangtjcu@163.com
基金资助:
国家自然科学基金项目
PANG Guang-chang,CHEN Qing-sen,HU Zhi-he
Received:
2011-10-31
Revised:
2011-12-27
Online:
2012-01-15
Published:
2012-01-12
Contact:
Pang guangchang
E-mail:pangtjcu@163.com
摘要:
为什么乳酸菌及其发酵食品往往有利于健康?或许这正是由于其产乳酸盐的作用。乳酸盐代谢已经得到了生理和生物化学家的广泛关注。然而,20世纪的前叶,乳酸盐还一直被作为废物,特别是作为肌肉疲劳的罪魁祸首。但是最近,越来越多的研究结果证明,乳酸盐在多细胞有机体中发挥了关键性作用。已经证明乳酸有多种生理功能,可以作用于机体的激素释放、调节多种酶活性,控制机体代谢平衡。此外,这些特性还直接关系到病理作用的发生和发展,如糖尿病和癌症。乳酸盐不能简单地认为是一种厌氧发酵产物,其实更应该把它作为一个调节分子,可以调节和整合多条代谢途径。虽然乳酸盐本身并不是一种具氧化还原作用的化合物,但是,它作为一种重要的中间代谢产物参与了糖酵解、生物氧化和生物合成。乳酸盐在胞浆中由糖酵解途径合成,通过和丙酮酸之间的互相转化与NADH/NAD+偶联,由乳酸脱氢酶催化。所以乳酸盐在NADH/NAD+、pH值、ATP、生物氧化与合成的动态平衡中发挥着重要作用。也正是因为这些生物活性,乳酸盐已经被广泛应用于发酵和功能性食品生产、肉类食品质量保护和护色、防癌、抗癌;同时,乳酸盐还是生理变化、应激和病理评估的理想标志物。
中图分类号:
庞广昌,陈庆森,胡志和. 乳酸盐代谢及其在健康中的关键作用[J]. 食品科学, 2012, 33(1): 1-15.
PANG Guang-chang,CHEN Qing-sen,HU Zhi-he. Metabolism of Lactate and Its Critical Role in Health[J]. FOOD SCIENCE, 2012, 33(1): 1-15.
[1] Shinji Fukuda, Hidehiro Toh, Koji Hase, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate [J], Nature, 2011, Vol.469:543-549.[2] Shan-na Liu, Ye Han, Zhi-jiang Zhou, Lactic acid bacteria in traditional fermented Chinese foods [J], Food Research International, 2011,44 643–651.[3] Frederic Langevin1, Gerry P. Crossan1, Ivan V. Rosado1, et al. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice [J] Nature,2011,Vol.475:53-59.[4] 于立芹,庞广昌,戴懿,乳酸对主要发炎和抗炎细胞因子的影响,食品科学,2007,Vol.28,No.12,439-442.[5] George A. Brooks,Cell–cell and intracellular lactate shuttles [J],J Physiol 587.23 (2009) pp 5591–5600.[6] Andrew Philp, Adam L. Macdonald, and Peter W. Watt, Lactate – a signal coordinating cell and systemic function [J], The Journal of Experimental Biology, 2005, 208, 4561-4575.[7] BrooksGA, BrownMA, Butz CE, et al., HMCT1 in cardiac and skeletal muscle mitochondria [J]. J Appl Physiol, 1999, 87:1713–1718. [8] Pagliarini DJ, Calvo SE, Chang B, et al., A mitochondrial protein compendium elucidates complex I disease biology [J], Cell, 2008,134:112–123.[9] Kline ES, Brandt RB, Laux JE, et al., Localization of L-lactate dehydrogenase in mitochondria. Arch Biochem Biophys [J], 1986, 246:673–680.[10] Brandt RB, Laux JE, Spainhour, et al., Lactate dehydrogenase in mitochondria. Arch Biochem Biophys [J], 1987, 259:412–422.[11] Brooks GA, Dubouchaud H, Brown M, et al., Role of mitochondrial lactic dehydrogenase and lactate oxidation in the ‘intra-cellular lactate shuttle’ [J], Proc Natl Acad Sci USA, 1999, 96:1129–1134.[12] Brooks GA, Lactate shuttles in nature [J], Biochem Soc Trans, 2002, 30:258–264.[13] Passarella S, de Bari L, Valenti D, et al., Mitochondria and L-lactate metabolism [J], FEBS Lett, 2008, 582:3569–3576.[14] McClelland GB, Khanna S, Gonz′alez G, et al. Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system? [J], Biochem Biophys Res Commun, 2003, 203:130–135.[15] Chatham JC, Des Rosiers C & Forder JR, Evidence of separate pathways for lactate uptake and release by the perfused rat heart [J], Am J Physiol Endocrinol Metab, 2001, 281:794–802.[16] Brooks GA,Lactate: Glycolytic end product and oxidative substrate during sustained exercise in mammals –the ‘lactate shuttle’. In Circulation, Respiration, and Metabolism: Current Comparative Approaches[M], ed. Gilles R, Springer-Verlag, Berlin, 1985, pp. 208–218.[17] Brooks GA & Donovan CM, Effect of training on glucose kinetics during exercise [J], Am J Physiol Endocrinol Metab, 1983, 244:505–512.[18] Mazzeo RS, Brooks GA, Schoeller DA & Budinger TF, Disposal of [1-13C]-lactate during rest and exercise [J], J Appl Physiol, 1986, 60:232–241.[19] Stanley WC, Gertz EW, Wisneski JA, et al., Lactate metabolism in exercising human skeletal muscle: Evidence for lactate extraction during net lactate release [J], J Appl Physiol, 1986, 60:1116–1120.[20] Bergman BC, Wolfel EE, Butterfield GE, et al., Active muscle and whole body lactate kinetics after endurance training in men [J], J Appl Physiol, 1999, 87:1684–1696.[21] Gertz EW, Wisneski JA, Stanley WCet al., Myocardial substrate utilization during exercise in humans. Dual carbon-labelled carbohydrate isotope experiments [J], J Clin Invest, 1988, 82:2017–2025.[22] Garcia CK, Goldstein JL, Pathak RK,et al., Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle [J], Cell, 1994, 76:865–873.[23] Price NT, Jackson VN & Halestrap AP, Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J, 1998, 329:321–328.[24] Bergman BC, Wolfel EE, Butterfield GE, et al., Active muscle and whole body lactate kinetics after endurance training in men [J], J Appl Physiol, 1999, 87:1684–1696.[25] Dubouchaud H, Butterfield GE, Wolfel EE, et al., Endurance training, expression and physiology of LDH, MCT1 and MCT4 in human skeletal muscle [J], Am J Physiol Endocrinol Metab, 2000, 278:571–579.[26] Gertz EW, Wisneski JA, Stanley WC, et al. Myocardial substrate utilization during exercise in humans. Dual carbon-labelled carbohydrate isotope experiments [J], J Clin Invest, 1988, 82:2017–2025.[27] Trimmer JK, Schwarz JM, Casazza GA, et al., Measurement of gluconeogenesis in exercising men by mass isotopomer distribution analysis [J], J Appl Physiol, 2002, 93:233–241.[28] Shimizu H., Watanabe E., Hiyama T.Y., et al., Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing [J], Neuron, 2007, 54:59–72.[29] Lam T.K., Gutierrez-Juarez R., Pocai A., et al., Regulation of blood glucose by hypothalamic pyruvate metabolism [J], Science, 2005, 309:943–947. [30] Gordon G.R., Choi H.B., Rungta R.L.,et al., Brain metabolism dictates the polarity of astrocyte control over arterioles [J], Nature, 2008, 456:745–49.[31] L. Felipe Barros, Joachim W. Deitmer, Glucose and lactate supply to the synapse [J], Brain research reviews, 2010(63):149–159.[32] Dringen R., Gebhardt R., Hamprecht, B., Glycogen in astrocytes: possible function as lactate supply for neighboring cells [J], Brain Res, 1993, 623:208–214.[33] Walls A.B., Heimbürger C.M., Bouman S.D., et al., Robust glycogen shunt activity in astrocytes: effects of glutamatergic and adrenergic agents [J], Neuroscience, 2009, 158:284–292.[34] Cruz N.F., Ball K.K., Dienel G.A., Functional imaging of focal brain activation in conscious rats: impact of [(14)C]glucose metabolite spreading and release [J], J. Neurosci. Res, 2007, 85: 3254–3266.[35] Rouach N., Koulakoff A., Abudara V., et al., Astroglial metabolic networks sustain hippocampal synaptic transmission [J], Science, 2008, 322:1551–1555.[36] Gandhi G.K., Cruz N.F., Ball K.K.,et al., Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons [J], J. Neurochem, 2009, 111:522–536.[37] 董佳康,庞广昌,发酵乳中乳酸的多种生理功能[J], 食品科学,2010, Vol. 31, No. 17:480-486.[38] Brooks, G A, Mercier, J., Balance of carbohydrate and lipid utilization during exercise: the ‘crossover’ concept[J], Appl. Physiol, 1994, 76:2253-2261.[39] Philp, A, Adam L,Watti P W., Lactate – a signal coordinating cell and systemic function[J].The Journal of Experimental Biology, 2008, 208:4561-4575.[40] Corbett J, Fallowfield J L, Sale C, et al. Relationship between plasma lactate concentration and fat oxidation[J].Annu. Congr. Eur. Coll. Sports Sci, 2004, 107:172.[41] Berzelius, J. J., Djurkemien. Stockholm: Marquard[M]. 1808.[42] Westerblad H, Allen D G, Lannergren J.Muscle fatigue: lactic acid or inorganic phosphate the major cause?[J].News Physiol. Sci,2002, 17: 17-21.[43] Nielsen O B, De Paoli F, Overgaard K.Protective effects of lactic acid on force production in rat skeletal muscle[J]. J.Physiol,2001,536:161-166.[44] Riekelt H. Houtkooper, Carles Canto, Ronald J. Wanders, and Johan Auwerx,The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways [J], Endocrine Reviews, April 2010, 31(2):194–223.[45] Warburg O, Posener K, Negelein E (1924) Uber den stoffwechsel der carcinomzelle [J], Biochem Z 152:309.[46] Pasteur, L. (1861) Experiments and novel views on the nature of fermentation [J], Comp. Rend. Acad. Sci., 89, 1260-1264.[47] Douglas Hanahan, and Robert A. Weinberg, Hallmarks of Cancer: The Next Generation [J], Cell 2011(144): 646-674.[48] William G. Kaelin Jr and Craig B. Thompson, Clues from cell metabolism [J], Nature, 2010(465):562-564.[49] Ismael Samudio, Michael Fiegl, and Michael Andreeff, Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism [J], Cancer Res 2009, 69(6): 2163-2166.[50] Chiang Y, Chou CY, Hsu KF, et al., EGF upregulates Na+/H+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness [J], J Cell Physiol, 2008, 214:810-819.[51] De Milito A, Canese R, Marino ML, et al., pH dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity [J], Int J Cancer, 2010, 127:207-219.[52] Zhang X, Lin Y, Gillies RJ, Tumor pH and its measurement [J], J Nucl Med, 2010, 51:1167-1170.[53] Provent P, Benito M, Hiba B, et al., Serial in vivo spectroscopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gliomas shows redistribution of protons away from sites of glycolysis [J], Cancer Res, 2007, 67:7638-7645.[54] Halestrap AP, Price NT, The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation [J], Biochem J, 1999, 343:281-299.[55] Emmanuelle Grillon, Régine Farion, Katell Fablet, The Spatial Organization of Proton and Lactate Transport in a Rat Brain Tumor [J], "PLoS ONE 2011, 6(2):e17416, DOI: 10.1371/journal.pone.0017416[56] Miller BF, Fattor J, Jacobs KA, Horning MA, Suh S-H, Navazio F & Brooks GA. Lactate–glucose interaction in men during rest and exercising using lactate clamp procedure [J], J Physiol, 2002, 544, 963–975.[57] Brooks GA Mammalian fuel utilization during sustained exercise [J], Comp Biochem Physiol, 1998, 120, 89–107.[58] Liu C,Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F & Lovenberg TW Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81 [J], J Biol Chem, 2009, 284, 2811–2822.[59] Brooks GA, Lactate shuttles in nature. Biochem Soc Trans, 2002, 30, 258–264.[60] Henderson GC, Horning MA, Lehman SL,Wolfel EE, Bergman & Brooks GA. Pyruvate shuttling during rest and exercise in men before and after endurance training [J], J Appl Physiol, 2004, 97, 317–325.[61] Garcia CK, Goldstein JL, Pathak RK, Anderson RG & Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle [J], Cell, 1994, 76, 865–873.[62] Price NT, Jackson VN & Halestrap AP. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past [J], Biochem J, 1998, 329, 321–328.[63] McClelland GB, Khanna S, Gonz′alez G, Butz CE & Brooks GA. Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system? [J], Biochem Biophys Res Commun, 2003, 203, 130–135.[64] Hashimoto T, Hussien R, Oommen S, Gohil K & Brooks GA. Lactate sensitive transcription factor network in L6 myocytes: activation of MCT1 expression and mitochondrial biogenesis [J], FASEB J, 2007, 21, 2602–2612.[65] Devadoss J. Samuvel, Kamala P. Sundararaj, Alena Nareika, et al. Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation [J], The Journal of Immunology, 2009, 182: 2476–2484.[66] Riekelt H. Houtkooper, Carles Canto , Ronald J. Wanders, et al. The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways [J], Endocrine Reviews, April 2010, 31(2):194–223.[67] Rydstrom J Mitochondrial NADPH, transhydrogenase and disease [J], Biochim Biophys Acta 2006, 1757:721–726.[68] Sauve AA, Wolberger C, Schramm VL, et al. The biochemistry of sirtuins [J], Annu. Rev. Biochem. 2006, 75:435–465.[69] Kaeberlein M, McVey M, Guarente L The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms [J], Genes Dev 1999,13:2570–2580.[70] Guarente L, Sir2 links chromatin silencing, metabolism, and aging [J], Genes Dev. 2000, 14:1021–1026.[71] Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan [J], Nature, 2003, 425:191–196.[72] Lin SJ, Kaeberlein M, Andalis AA, et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration [J], Nature, 2002, 418:344–348.[73] Rogina B, Helfand SL,Sir2 mediates longevity in the fly through a pathway related to calorie restriction [J], Proc Natl Acad Sci USA, 2004, 101:15998–16003.[74] Rodgers JT, Lerin C, Haas W, et al. Nutrient control of glucose homeostasis through a complex of PGC-1 and SIRT1 [J], Nature, 2005, 434: 113–118 83.[75] Canto, C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity [J], Nature, 2009, 458:1056–1060.[76] Anand Mohan, M.C. Hunt, T.J. Barstow, et al. Effects of malate, lactate, and pyruvate on myoglobin redox stability in homogenates of three bovine muscles [J], Meat Science, 2010, 86:304–310.[77] R. Ramanathan, R.A. Mancini, G.A. Dady, Effects of pyruvate, succinate, and lactate enhancement on beef longissimus raw color [J], Meat Science, 2011, 88:424–428.[78] Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB: Brick by brick: metabolism and tumor cell growth [J], Curr Opin Genet Dev 2008, 18:54-61.[79] Freund E: Zur Diagnose des Carzinoms. Vorl?ufige Mittheilung [J], Wien Med Bl 1885, 8:267.[80] H?ndel M, Tadenuma K: über die Beziehung des Geschwulstwachstums zur Ern?hrung und zum Stoffwechsel. II. Mitteilung. Versuche zur Frage der Bedeutung der Kohlenhydrate für das Wachstum des Rattencarzinoms [J], Z Krebsforsch (J Cancer Res and Clin Oncol) 1924, 21:288-293.[81] Marks PA, Bishop JS: The glucose metabolism of patients with malignant disease and of normal subjects as studied by means of an intravenous glucose tolerance test [J], J Clin Invest 1957, 36:254-264.[82] Zuijdgeest-van Leeuwen SD, van den Berg JW, Wattimena JL, van der Gaast A, Swart GR, Wilson JH, Dagnelie PC: Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects [J], Metabolism 2000, 49:931-6.[83] Skinner R, Trujillo A, Ma X, Beierle EA: Ketone bodies inhibit the viability of human neuroblastoma cells [J], J Pediatr Surg 2009, 44:212-6.[84] Wilder RM: The effect of ketonemia on the course of epilepsy [J], Mayo Clin Bulletin 1921, 2:307-308.[85] Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, Whitney A, Cross JH: The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial [J], Lancet Neurol 2008, 7:500-506.[86] Wiznitzer M: From observations to trials: the ketogenic diet and epilepsy [J], Lancet Neurol 2008, 7:471-472.[87] Nebeling LC, Miraldi F, Shurin SB, Lerner E: Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports [J], J Am Coll Nutr 1995, 14:202-208.[88] Zuccoli G, Marcello N, Pisanello A, Servadei F, Vaccaro S, Mukherjee P, Seyfried TN: Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report [J], Nutr Metab (Lond) 2010, 22:33.[89] Magee BA, Potezny N, Rofe AM, Conyers RA: The inhibition of malignant cell growth by ketone bodies [J], Aust J Exp Biol Med Sci 1979, 57:529-539.[90] Fine EJ, Miller A, Quadros EV, Sequeira JM, Feinman RD: Acetoacetate reduces growth and ATP concentration in cancer cell lines which overexpress uncoupling protein 2 [J], Cancer Cell Int 2009, 29:14.[91] Freedland SJ, Mavropoulos J, Wang A, Darshan M, Demark-Wahnefried W, Aronson WJ, Cohen P, Hwang D, Peterson B, Fields T, Pizzo SV, Isaacs WB:Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis [J], Prostate 2008, 68:11-19.[92] Hardman WE: Dietary canola oil suppressed growth of implanted MDAMB 231 human breast tumors in nude mice [J], Nutr Cancer 2007, 57:177-183.[93] Otto C, Kaemmerer U, Illert B, et al. Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides [J], BMC Cancer BMC Cancer 2011, 11:315 doi:10.1186/1471-2407-11-315.[94] Melanie Schmidt, Nadja Pfetzer, Micheal Schwab, Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial [J], Nutrition & Metabolism 2011, 8:54-67.[95] Laktat als Endprodukt und Brennstoff,Lactate as an End-Product and Fuel [J], Deutsche Zeitschriftfür Sportmedizin, 2010, 61(5):112-116.[96] Alice Limonciel, Lydia Aschauer, Anja Wilmes et al. Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes [J], Toxicol. in Vitro (2011), doi:10.1016/j.tiv.2011.05.018[97] Jeffrey P. Green, MD, Tony Berger, MD, MS, et al. Serum Lactate Is a Better Predictor of Short-Term Mortality When Stratified by C-reactive Protein in Adult Emergency Department Patients Hospitalized for a Suspected Infection [J], Annals of Emergency Medicine, 2011, 57(3):291-295. |
[1] | 陆敏涛,任廷远,杨建,陆龙发,秦礼康. 花椒精油对链脲佐菌素诱导的糖尿病小鼠糖代谢的影响[J]. 食品科学, 2021, 42(9): 115-122. |
[2] | 张舒,王长远,冯玉超,盛亚男,富天昕,张艺玮,姜颖俊,于淼,张丽媛. 气相色谱-质谱联用代谢组学技术分析不同产地稻米代谢物[J]. 食品科学, 2021, 42(8): 206-213. |
[3] | 杨忠敏,沈以红,黄先智,王祖文,丁晓雯. 桑叶生物碱对氧化应激小鼠糖脂代谢异常及肝损伤的改善作用[J]. 食品科学, 2021, 42(7): 156-161. |
[4] | 袁帅,鲁丁强,庞广昌. ‘印度青’苹果合成与分解代谢通量研究及贮藏温度的优化[J]. 食品科学, 2021, 42(7): 214-219. |
[5] | 郎晨晓,张一敏,朱立贤,梁荣蓉,毛衍伟,杨啸吟,韩广星,罗欣,董鹏程. 牛肉低温贮藏环境中沙门氏菌诱导耐酸响应的存在程度及其产生机制[J]. 食品科学, 2021, 42(6): 68-74. |
[6] | 刘晗璐,张九凯,韩建勋,孙瑞雪,陈颖,刘冰. 基于UPLC-QTOF-MS代谢组学技术的NFC和FC橙汁差异成分比较[J]. 食品科学, 2021, 42(6): 229-237. |
[7] | 王耀松,马天怡,胡荣蓉,张唯唯,应瑞峰,黄梅桂,唐长波. L-组氨酸修饰乳清蛋白结构及其热诱导凝胶特性[J]. 食品科学, 2021, 42(6): 16-23. |
[8] | 王苗,张保杰,文佳嘉,胡婕伦,聂少平,谢明勇. 两种乳酸杆菌对肥胖小鼠的干预作用[J]. 食品科学, 2021, 42(5): 152-159. |
[9] | 李玲,李智,石玲,李亚玲,何欢,张亚琳,芦玉佳,朱璇. 臭氧对杏果实黑斑病的抑制及贮藏保鲜作用[J]. 食品科学, 2021, 42(5): 215-220. |
[10] | 王彩霞,白婵,熊光权,王炬光,李宁,鉏晓艳,李海蓝,廖涛. 丁香酚麻醉辅助加州鲈无水活运的效果[J]. 食品科学, 2021, 42(5): 228-236. |
[11] | 赵媚,常凌,宋泽和,贺喜. 植物多酚与肠道微生物群的相互作用及其对代谢性疾病影响的研究进展[J]. 食品科学, 2021, 42(5): 305-313. |
[12] | 吴晓娟,王晓婵,张佳妮,沈佳丽,李依,金曼芹,吴伟. pH值碱性偏移结合热处理对米糠蛋白结构和功能性质的影响[J]. 食品科学, 2021, 42(4): 23-30. |
[13] | 康子悦,沈蒙,葛云飞,王娟,全志刚,肖金玲,王维浩,曹龙奎. 基于植物广泛靶向代谢组学技术探究小米粥中酚类化合物组成及其抗氧化性[J]. 食品科学, 2021, 42(4): 206-214. |
[14] | 李华健,陈韬,杨波若,李霞,李燕清,王博文,卞健科,舒国涛. 宰后猪肉pH值、骨架蛋白表达水平和持水性之间的关系[J]. 食品科学, 2021, 42(3): 14-20. |
[15] | 杜健,梁井瑞,韩宗正,任建威,赵媛,李伟,王剑,冯晓慧. 二十二碳六烯酸微藻油乳状液稳定性的影响因素[J]. 食品科学, 2021, 42(3): 85-91. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||