食品科学

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矢车菊-3-葡萄糖的抗癌效应研究进展

陈 亮1,2,辛秀兰2,袁其朋1,*   

  1. 1.北京化工大学 化工资源有效利用国家重点实验室,北京 100029;2.北京电子科技职业学院生物工程学院,北京 100029
  • 出版日期:2013-07-15 发布日期:2013-06-28
  • 通讯作者: 袁其朋
  • 基金资助:

    国家公益性行业(农业)科研专项(201103037);北京市属高等学校人才强教深化计划资助项目;
    北京市职业院校职教名师资助项目

Research Progress in Anticancer Effect of Cyanidin-3-glucoside

CHEN Liang1,2,XIN Xiu-lan2,YUAN Qi-peng1,*   

  1. 1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China;
    2. College of Bioengineering, Beijing Polytechnic, Beijing 100029, China
  • Online:2013-07-15 Published:2013-06-28
  • Contact: YUAN Qi-peng

摘要:

花色苷是一类天然的黄酮类化合物,广泛分布在人们日常饮食的水果蔬菜中。大量的流行病学与动物实验 研究表明花色苷具有癌症化学预防作用。本文总结了在大多数浆果及相关产品中分布最普遍、含量高的花色苷-矢 车菊-3-葡萄糖苷的抗癌效应,这种效应主要通过抗氧化、激活Ⅱ相解毒酶、抗细胞增殖、诱导细胞凋亡、抗炎效 应、抗血管生成、抗细胞侵入、诱导细胞分化等机制来发挥,本文概述了矢车菊-3-葡萄糖苷的癌症预防效应。

关键词: 花色苷, 矢车菊-3-葡萄糖苷, 抗癌效应

Abstract:

Anthocyanins are a group of naturally occurring flavonoid compounds, which is widely available in fruits
and vegetables in human diets. A lot of epidemiological and animal experiments have demonstrated that anthocyanins
may contribute to cancer chemoprevention. In this article, we summarize the anti-cancer effects and the mechanisms of
anthocyanins and cyanidin-3-glucoside (C3G) in berries and related food products on several key steps: antioxidant effects,
enzyme activation, anti-cell proliferation, apoptosis induction, anti-inflammation, anti-angiogenesis, anti-invasiveness,
and differentiation induction. This review provides a molecular view of cyanidin-3-glucoside contributing to cancer
chemoprevention.

Key words: anthocyanins, cyanidin-3-glucoside, anti-cancer effect

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