[1] 黄年来,林志彬,陈国良,等. 中国食药用菌学[M]. 上海:上海科学技术文献出版社,2010:1763.[2] 梁宗琦. 中国真菌志第32卷-虫草属[M]. 北京:科学出版社,2007:10-47.[3] NAG T B, WANG Hexiang. Pharmacological actions of Cordyceps, a prized folk medicine[J]. Journal of Pharmacy and Pharmacology, 2005, 57:1509-1519.[4] 肖亦农,韩梅,赵春燕. 不同培养基对蛹虫草子实体甘露醇、多糖和矿质元素含量的影响[J]. 沈阳农业大学学报,2009,40(2):227-229.[5] 陈宏伟,陈安徽,邵颖,等. 蛹虫草胞外锌多糖抗氧化能力的研究[J]. 食品与发酵工业,2009,35(6):54-58.[6] 胡丰林,李增智. 虫草及相关真菌的次生代谢产物及其活性[J]. 菌物学报,2007,26(4):607-632.[7] 陈畅,罗珊珊,李彦,等. 三种虫草抗氧化活性的化学发光法研究[J]. 上海中医药杂志,2004,38(7):53-55.[8] 杨昕,斯陆勤,涂秩平,等. 不同产地人工蛹虫草子实体及冬虫夏草中核苷类成分的比较[J]. 医药导报, 2009,28(10):1354-1356.[9] 曾宏彬,宋斌,李泰辉. 蛹虫草研究进展及其产业化前景[J]. 食用菌学报,2011,18(2):70-74.[10] R.J. 苏哈道尼克著(谢其明,王恕蓉译)核苷类抗菌素[M]. 北京:科学出版社,1982:476.[11] 焦彦朝,梁宗琦,刘爱英. 虫草生物活性物质研究概况[J]. 贵州农业科学,1990,(3):53-54.[12] 抗菌素生物理化特性编写组,抗菌素生物理化特性(第一分册)[M]. 北京:人民出版社,1977:983.[13] CUNNINGHAM KG, MANSON W, SPRING FS, et al. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link[J]. Nature, 1950, 166(4231): 949.[14] CUNNINGHAM KG, HUTCHINSON SA, MANSON W, et al. Cordycepin, a metabolic product from cultures of Cordyceps militaris Link. Part I. Isolation and characterization[J]. Journal of Chemical Society, 1951, 2: 2299-3000.[15] FREDERIKSEN S, MALLING H, KLENOW H. Isolation of 3′-deoxyadenosine (cordycepin) from the liquid medium of Cordyceps militaris (L. ex Fr.) Link[J]. Biochimica et Biophysica Acta, 1965, 95(2): 189-193.[16] KACZKA EA, TRENNER NR, ARISON B, et al. Identification of cordycepin, a metabolite of Cordyceps militaris, as 3′-deoxyadenosine[J]. Biochemical and Biophysical Research Communications, 1964, 14: 456-457.[17] YOSHIDA J, TAKAMURA S, YAMAGUCHI N, et al. Antitumor activity of an extract of Cordyceps sinensis (Berk.)Sace. against murine tumor cell lines[J].The Japanese Journal of Experimental Medicine.1989, 59(4):157-161 [18] 吴洪臻,江伟,马德恩.虫草菌素对小鼠 S180 瘤抑制作用研究[J].时珍国医国药,2000,11(10):873-874.[19] PARK SJ,MYOUNG H,KIM YY,et al. Anticancer effects of genistein, green tea catechins, and cordycepin on oral squamous cell carcinoma [J]. Journal of the Korean Association of Oral and Maxillofacial Surgeons,2008,34(1):l-10.[20] KYOSHIKAWA N,YKAGOTA NY,KKUNITOMO M SS. Antitumor effect of cordycepin (3′-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation[J].Anticancer Research,2006,26(1):43-47.[21] FULLER B B, LUNSFORD J B, IMAN D S. Alpha-melanocyte-stimulating hormone regulation of tyrosinase in cloudman S-91 mouse melanoma cell cultures[J].The Journal of Biological Chemistry,1987, 262(9):4024-4033.[22] EIICHI N. KODAMA, Ronald P. MCCAFFREY, K Y. Antileukemic activity and mechanism of action of Cordycepin against termnal deoxynucleotidal transferase-positive(TdT) leukemic Cells[J].Biochemical Pharmacology, 2000, (59):273-281.[23] 李婧, 姜汉英. 虫草素的体内代谢特点及药理作用[J].国外医学?中医中药分册,2005,27(5):283-285.[24] 彭俊峰,凌建亚,张晗星,等. 虫草素与DNA作用的光谱研究[J].光谱学与光谱分析,2004,24(7):858-861.[25] KOC Y,URBACO A G,SWEENEY E B,et al Induction of apoptosis by cordycepin in ADA-inhibited TdT positive leukemia cel1s[J].Leukemia, 1996, 10(6):1019-1024.[26] GLAZER R I, LOTT T J, PEALE A L. Potentiation by 2′-deoxycoformycin of the inhibitory effect by 3′-deoxyadenosine (cordycepin) on nuclear RNA synthesis in L1210 cells in vitro[J]. Cancer Research, 1978, 38(8):2233-2238.[27] 戴小军,柳冬梅,孟霞. 冬虫夏草抗癌作用研究现状[J]. 时珍国医国药,2000,11(4):376.[28] ZHOU Xiaoxia, Claudius U M,PRTER S, et al. Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cell[J].European Journal of Pharmacology, 2002,(453):309-317.[29] 蔡友华,刘学铭. 虫草素的研究与开发进展[J]. 中草药,2007,38(8):1269-1272.[30] 李婧,汪燕,马传荣,等. 国产虫草素抗小鼠迟发型超敏反应的实验研究[J]. 中国免疫学杂志,2006,(5):456-458.[31] KUO Yuh-Chi, TSAI Wei-Jem, SHIAO Ming-Shi, et al. Cordyceps sinensis as an Immunomodulatory Agent [J]. American Joural of Chinese Medicine, 1996,24(2):111-125.[32] FAN Baoyan, ZHANG Haibo. Cordycepin: pharmacological properties and their relevant mechanisms[J]. TANG, 2012, 2(2):e14, 1-7.[33] 康冀川,康超,文庭池,等. 虫草菌素药理学研究进展[J]. 菌物学报,2011,30(2):191-197.[34] 李祝,刘爱英,梁宗琦. 虫草菌素的生物活性及检测方法[J]. 食用菌学报,2002,9(1):57-61.[35] NAKAMURA K, YOSHIKAWA N, YAMAGUCHI Y, et al. Antitumor effect of cordycepin on mouse mela-noma and lung carcinoma cells involves adenosine A3 receptor stimulation[J]. Anticancer Research, 2006,26(IA):43-47.[36] KIM HG,SHRESTH B,LIM SY,et al. Cordycepin inhibits lipopolysaccharide-induced inflammation by thesuppression of NF-κB through Akt and p38 inhibition in RAW264.7 macrophage cells [J].European Journal of Pharmacology, 2006,545(2):192-199.[37] REN Zhenghua, CUI Jianhua,HUO Zeren,et al. Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination[J]. International Immunopharmacology, 2012,14(4):698-703.[38] CHANG W,LIMA S,SONG H,et a1.Cordycepin inhibits vascular smooth muscle cell proliferation[J].European Journal of Pharmacology, 2008,597(1):64-69.[39] CHO HJ,CHO JY,RHEE MH,et al.Cordycepin(3'-deoxyadenosine)inhibits human platelet aggregation in a cyclic AMP-and cyclic GMP-dependent manner[J].European Journal of Pharmacology, 2007,558(1):43-51.[40] 吴勇,陈卫东. 蛹虫草药理作用研究概述[J]. 中国药师,2011,14(5):732-734.[41] MASTER P, VOGEL D, SCHMID C, et a1. Identification and characterization of trypanocides by functional expression of an adenosine transporter from Trypanosoma brucei in yeast[J].Journal of Molecular Medicine, 2001, 79(2):121-127.[42] 文庭池,李光荣,康冀川,等. 蛹虫草液体种制备及发酵生产菌丝体和虫草菌素工艺优化[J]. 食品科学,2012,33(5):144-149.[43] 刘艳芳,唐庆九,顾俊杰,等. 北冬虫夏草深层发酵高产虫草素工艺的优化[J]. 上海农业学报,2010,26(3):26-30.[44] 李祝,郁建平,梁宗琦,等 . 前体物质与真菌激发子对虫草菌素产量的影响[J]. 食品科学,2008,29(6):273-275.[45] 毛先兵, 涂永勤. 采用氨基酸补料分批培养策略促进蛹虫草生产虫草素的研究[J]. 重庆中草药研究. 2005,(1):18-22.[46] XIE Chunyan, GU Zhenxin, FAN Gongjian, et al. Production of cordycepin and mycelia by submerged fermentation of Cordyceps militaris in mixture natural culture[J]. Applied Biochemistry and Biotechnology, 2009, 158(2): 483-492.[47] FAN Dandan,WANG Wei,ZHONG Jianjiang. Enhancement of cordycepin production in submerged cultures of Cordyceps militaris by addition of ferrous sulfate[J]. Biochemical Engineering Journal, 2012,60: 30-35.[48] MAO Xianbing, ZHONG Jianjiang. Significant effect of NH4+ on cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris[J]. Enzyme and Microbial Technology, 2006, 38: 343-350.[49] HUNG LT,KEAWSOMPONG S, HANH VT,et al. Effect of temperature on cordycepin production in Cordyceps militaris[J]. Thai Journal of Agricultural Science, 2009,42(4): 219-225.[50] SHIH Ing-Lung,TSAI Kun-Lin,HSIEH Chienyan. Effects of culture conditions on the mycelial growth and bioactive metabolite production in submerged culture of Cordyceps militaris[J]. Biochemical Engineering Journal, 2007,33: 193-201.[51] MASUDA M, URABE E, SAKURAI A, et al. Production of cordycepin by surface culture using the medicinal mushroom Cordyceps militaris[J]. Enzyme and Microbial Technology, 2006, 39: 641-646.[52] MASUDA M, URABE E, HONDA H, et al. Enhanced production of cordycepin by surface culture using the medicinal mushroom Cordyceps militaris[J]. Enzyme and Microbial Technology, 2007, 40: 1199-1205.[53] DAS S K, MASUDA M, HATASHITA M, et al. A new approach for improving cordycepin productivity in surface liquid culture of Cordyceps militaris using high-energy ion beam irradiation[J]. Letters in Applied Microbiology, 2008, 47: 534-538.[54] DAS S K, MASUDA M, SAKURAI A, et al. Effects of additives on cordycepin production using a Cordyceps militaris mutant induced by ion beam irradiation[J]. African Journal of Biology, 2009, 8(13): 3041-3047.[55] DAS S K, MASUDA M, HATASHITA M, et al. Optimization of culture medium for cordycepin production using Cordyceps militaris mutant obtained by ion beam irradiation[J]. Process Biochemistry, 2010, 45: 129-132.[56] MASUDA M, DAS S K, FUJIHARA S, et al. Production of cordycepin by a repeated batch culture of a Cordyceps militaris mutant obtained by proton beam irradiation[J]. Journal of Bioscience and Bioengineering, 2011, 111(1): 55-60.[57] 温鲁,夏敏,宋虎卫,等. 固体培养蛹虫草核苷类次生代谢物的产率[J]. 食品科学,2005,26(11):65-68.[58] 温鲁. 提高蛹虫草培养物中虫草素含量的研究[J]. 江苏农业科学,2005,(6):118-120.[59] 张红,于桂英,徐方旭,等. 辐射诱变高产虫草素蛹虫草菌株的研究[J]. 安徽农业科学,2011,39(27):16575-16576.[60] 莫红丽. 吖啶橙诱变提高蛹虫草虫草素含量的研究[J]. 广东蚕业,2011,45(2):23-26.[61] 李文,赵世光,陈宏伟,等. 低能离子束修饰蛹虫草菌株高产虫草素[J]. 生物工程学报,2009, 25(11): 1725-1731.[62] 温鲁,张诚,夏敏,翁梁,蛹虫草航天搭载对活性成分含量的影响[J]. 食品科学,2008,29(5):382-384[63] 张红霞,黄开华,陈伟,等. 蛹虫草不同栽培菌株产虫草素及腺苷差异性研究[J]. 食用菌,2011(5):63-64.[64] 谭琪明,何琚,文庭池,等. 蛹虫草小麦培养基中虫草素提取工艺研究术[J]. 山地农业生物学报,2011,30(4):357-361.[65] 孙军德,白立红,房琳琳,等. 蛹虫草中虫草素测定方法的比较[J]. 沈阳农业大学学报,2011,42(2):212-215.[66] NI He, ZHOU Xiaohong, LI Haihang, et al. Column chromatographic extraction and preparation of cordycepin from Cordyceps militaris waster medium[J]. Journal of Chromatography B, 2009, 877: 2135-2141.[67] YU Rongmin, YE Bin, YAN Chunyan, et al. Fingerprint analysis of fruiting bodies of cultured Cordyceps militaris by high-performance liquid chromatography-photodiode array detection[J]. Journal of Pharmaceutical Biomedical Analysis. 2007, 44: 818-823.[68] RAO Y K, CHOU C H, TZENG Y M. A simple and rapid method for identi?cation and determination of cordycepin in Cordyceps militaris by capillary electrophoresis[J]. Analytica Chimica Acta, 2006, 566: 253-258.[69] 黄兰芳,郭方遒,梁逸曾,等. HPLC-ESI-MS测定冬虫夏草和蚕蛹虫草中腺苷和虫草素含量[J]. 中国中药杂志,2004,29(8):764-764.[70] 欧阳召,王春梅, 陶志. 适合虫草素积累的蛹虫草液体培养条件的优化[J]. 中国食用菌,2012, 31(1):26-28.[71] 杨涛,董彩虹. 虫草素的研究开发现状与思考[J]. 菌物学报,2011,30(2): 180-190 |