食品科学 ›› 2020, Vol. 41 ›› Issue (1): 258-266.doi: 10.7506/spkx1002-6630-20181206-076

• 专题论述 • 上一篇    下一篇

表没食子儿茶素没食子酸酯性质、稳定性及其递送体系的研究进展

闫晓佳,梁秀萍,李思琪,刘畅,刘夫国   

  1. (西北农林科技大学食品科学与工程学院,陕西 杨凌 712000)
  • 出版日期:2020-01-15 发布日期:2020-01-19
  • 基金资助:
    国家自然科学基金青年科学基金项目(21808187)

Advances in the Properties, Stability and Delivery Systems of (-)-Epigallocatechin-3-gallate: A Review

YAN Xiaojia, LIANG Xiuping, LI Siqi, LIU Chang, LIU Fuguo   

  1. (College of Food Science and Engineering, Northwest A & F University, Yangling 712000, China)
  • Online:2020-01-15 Published:2020-01-19

摘要: 表没食子儿茶素没食子酸酯((-)-epigallocatechin-3-gallate,EGCG)是从绿茶中提取的儿茶素类单体,是茶多酚的主要成分。由于EGCG结构中含有多个酚羟基,其具有较强的抗氧化活性,而且在抗肿瘤、心血管疾病预防等方面可发挥重要作用。然而,EGCG易受外界环境(如光照、高温、pH值等)影响而发生氧化降解。通过构建纳米载体,例如蛋白质-多糖纳米颗粒、脂质体和水凝胶等,能够有效解决EGCG稳定性差、生物利用率低的问题。本文重点讨论了影响EGCG稳定性的各种因素以及不同递送体系对EGCG稳定性及功能特性的影响,以期为EGCG在食品和医药行业中的应用提供理论依据。

关键词: 表没食子儿茶素没食子酸酯, 性质, 稳定性, 生物利用率, 递送体系

Abstract: (-)-Epigallocatechin-3-gallate (EGCG) is a catechin monomer extracted from green tea, and is the main component of tea polyphenols. Because its structure contains a number of phenolic hydroxyl groups, EGCG has strong antioxidant activity and plays an important role in the fight against tumor and cardiovascular disease prevention. However, EGCG is susceptible to oxidation due to external factors such as light, high temperature and pH. Constructing nanocarriers (such as protein-polysaccharides based nanoparticles, hydrogels, and liposomes) can effectively solve the problem of poor stability and low bioavailability of EGCG. This paper mainly summarizes the factors affecting EGCG stability and the effects of different delivery systems on the stability and functional characteristics of EGCG, aiming to provide a theoretical basis for the application of EGCG in the food and pharmaceutical industries.

Key words: (-)-epigallocatechin-3-gallate, properties, stability, bioavailability, delivery systems

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