食品科学 ›› 2018, Vol. 39 ›› Issue (23): 272-279.doi: 10.7506/spkx1002-6630-201823040

• 专题论述 • 上一篇    下一篇

食源性细菌关键小分子信号通路研究进展

王飞飞1,傅玲琳1,鲍星月1,刘长军2,张晓双1,王彦波1,*   

  1. 1.浙江工商大学食品与生物工程学院,浙江食品质量安全工程研究院,浙江 杭州 310018;2.象山县水产技术推广站,浙江 象山 315700
  • 出版日期:2018-12-15 发布日期:2018-12-17
  • 基金资助:
    国家自然科学基金面上项目(31772050;31571913)

Advances in Understanding Key Small-Molecule Signaling Pathways of Foodborne Bacteria

WANG Feifei1, FU Linglin1, BAO Xingyue1, LIU Changjun2, ZHANG Xiaoshuang1, WANG Yanbo1,*   

  1. 1. Zhejiang Institute of Food Quality and Safety Engineering, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China; 2. Xiangshan Fisheries Technology Extension Center, Xiangshan 315700, China
  • Online:2018-12-15 Published:2018-12-17

摘要: 食源性细菌引起的食品腐败和生物被膜形成是食品科学领域关注的热点。研究表明这些现象与细菌群体感应(quorum sensing,QS)系统和第二信使环二鸟苷酸(cyclic di-guanosine monophosphate,c-di-GMP)系统密切相关,深入研究发现细菌可通过利用胞外自诱导物和胞内c-di-GMP分别感知细胞密度和外界刺激来调控一系列生理活性。鉴于此,本文主要围绕食品腐败和生物被膜形成关联的QS和c-di-GMP这两个系统,阐述食源性细菌关键小分子信号通路,探讨QS和c-di-GMP信号通路之间的调控网络,旨在更好地理解食品体系中细菌引起的腐败和生物被膜形成现象,提供保障食品品质与安全的控制靶点。

关键词: 食源性细菌, 群体感应, 环二鸟苷酸, 食品腐败, 生物被膜形成

Abstract: Food spoilage and biofilm formation by foodborne bacteria are hot topics in food science. The quorum sensing (QS) system and the secondary messenger cyclic di-guanosine monophosphate (c-di-GMP) have been reported to be involved in these phenomena. Intensive studies have demonstrated that bacteria can regulate a series of physiological processes via extracellular autoinducers and intracellular c-di-GMP, which perceive cell density and external stimulus, respectively. Considering this context, this review is focused on the QS and c-di-GMP signaling pathways and their effects on food spoilage and biofilm formation. The regulatory network between the two pathways is discussed as well. This review will be helpful to better understand the role of bacterial communication in food spoilage and biofilm formation in food system and to provide novel targets for ensuring food quality and safety.

Key words: foodborne bacteria, quorum sensing, cyclic di-guanosine monophosphate, food spoilage, biofilm formation

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