食品科学 ›› 2021, Vol. 42 ›› Issue (9): 355-361.doi: 10.7506/spkx1002-6630-20200418-240

• 专题论述 • 上一篇    

果蔬中外泌体样纳米颗粒的分离、表征和应用研究进展

杨梦楠,刘诗琦,张静,冉龙奕,陈忠加,马超   

  1. (1.北京林业大学生物科学与技术学院,北京 100083;2.北京林业大学工学院,北京 100083)
  • 出版日期:2021-05-15 发布日期:2021-06-02

Isolation, Characterization and Application of Exosome-Like Nanoparticles from Fruits and Vegetables: A Review

YANG Mengnan, LIU Shiqi, ZHANG Jing, RAN Longyi, CHEN Zhongjia, MA Chao   

  1. (1. College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China; 2. School of Technology, Beijing Forestry University, Beijing 100083, China)
  • Online:2021-05-15 Published:2021-06-02

摘要: 果蔬中的外泌体样纳米颗粒(exosome-like nanoparticles,ELNs)是由果蔬细胞释放的纳米级囊泡结构,与动物的外泌体具有类似的超微结构,但其脂质、蛋白质及核酸等化学成分具有显著差异,并具有独特的生物学功能。本文综述了2013年以来数十种果蔬中ELNs的相关研究进展,对其提取方法和表征手段进行了分析,重点分析了不同植物来源的ELNs中脂质、蛋白质和核酸类化学成分的组成差异,并对ELNs的潜在生理活性和载体功能进行了探讨,可为果蔬中ELNs的相关研究提供借鉴和启示。

关键词: 细胞外囊泡;外泌体;果蔬;载体

Abstract: The exosome-like nanoparticles (ELNs) in fruits and vegetables are nano-scale extracellular vesicles released by fruit and vegetable cells, with similar structures to the exosomes of mammal cells, and have significantly varying lipid, protein and nucleic acid profiles as well as unique biological functions. In this review, the progress that has been made in studies on the ELNs in dozens of fruits and vegetables since 2013 are summarized with a special focus on the methods used for ELNs extraction and characterization and on the differences in the chemical profiles including lipids, proteins, and nucleic acids of ELNs from different plant sources. Also, the potential health benefits and application as drug carriers of these ELNs are reviewed. This article is expected to provide enlightenments for further investigations on ELNs from fruits and vegetables.

Key words: extracellular vesicles; exosomes; fruits and vegetables; carrier

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