食品科学 ›› 2021, Vol. 42 ›› Issue (11): 26-33.doi: 10.7506/spkx1002-6630-20200425-330

• 基础研究 • 上一篇    下一篇

叶酸和辛烯基琥珀酸酐双修饰菊粉胶束对姜黄素的荷载特性

李若华,杨华,雷琳,叶发银,赵国华   

  1. (1.西南大学食品科学学院,重庆 400715;2.重庆市特色食品工程技术研究中心,重庆 400715)
  • 出版日期:2021-06-15 发布日期:2021-06-29
  • 基金资助:
    国家自然科学基金面上项目(31771932)

Curcumin Loading Properties of Folic Acid and Octenyl Succinic Anhydride Modified Inulin Micelles

LI Ruohua, YANG Hua, LEI Lin, YE Fayin, ZHAO Guohua   

  1. (1. College of Food Science, Southwest University, Chongqing 400715, China;2. Chongqing Engineering Research Center of Regional Food, Chongqing 400715, China)
  • Online:2021-06-15 Published:2021-06-29

摘要: 叶酸修饰两亲性多糖是一种有效的疏水活性物质载体,能增加疏水活性物质的结肠靶向转运。以叶酸和辛烯基琥珀酸酐双修饰菊粉(folic acid octenylsuccinate inulin,FA-OS-菊粉)自聚集形成荷载姜黄素的胶束为研究对象,以胶束颗粒粒径、多分散性指数和姜黄素保留率为指标,探究了该胶束的热处理稳定性、冻融稳定性、贮藏稳定性及体外模拟胃肠液消化稳定性和释放特性。结果:荷载姜黄素FA-OS-菊粉胶束在热处理和贮藏过程中姜黄素保留率较高,但粒径和多分散性指数变化显著;消化结束时,FA-OS-菊粉胶束在模拟胃液中的姜黄素释放率小于2%,在模拟肠液中的姜黄素释放率小于10%,具有较好的控释效果。结论:荷载姜黄素FA-OS-菊粉胶束具有潜在的结肠靶向效果。

关键词: 叶酸-辛烯基琥珀酸双修饰菊粉;胶束;姜黄素;稳定性;结肠靶向运输

Abstract: Folic acid conjugated with amphiphilic polysaccharide has been regarded as an effective carrier to delivery hydrophobic pheytochemicals to the colon. In our present study, the stability of self-assembled micelles of folic acid octenylsuccinate inulin (FA-OS-inulin) loaded with curcumin to thermal treatment, freeze-thaw treatment and simulated gastrointestinal digestion was investigated by the particle size and polydispersity index (PDI) of micelles as well as the retention of curcumin. Results showed that the micelles exhibited good thermal and storage stability with enhanced retention of curcumin. However, the particle size and PDI changed significantly during thermal processing and storage (P < 0.05). In the end of the gastrointestinal digestion, the percentage release of curcumin from the micelles was lower than 2% and 10% in simulated gastric and intestinal fluids respectively, indicating good controlled release properties. Therefore, FA-OS-inulin may be used as a potential vehicle for colon-targeted delivery of bioactive compounds like curcumin.

Key words: folic acid octenylsuccinate inulin; micelles; curcumin; stability; colon-targeted delivery

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