食品科学 ›› 2022, Vol. 43 ›› Issue (9): 310-316.doi: 10.7506/spkx1002-6630-20210409-111

• 专题论述 • 上一篇    下一篇

谷物蛋白及多肽调控2型糖尿病靶点研究进展

王晗,侯殿志,付永霞,赵卿宇,沈群   

  1. (中国农业大学食品科学与营养工程学院,国家粮食产业(青稞深加工)技术创新中心,国家果蔬加工工程技术研究中心,北京 100083)
  • 出版日期:2022-05-15 发布日期:2022-05-27
  • 基金资助:
    国家现代农业产业技术体系(CARS-06-14.5)

Progress in the Study of the Role of Grain Proteins and Peptides in Regulating the Therapeutic Targets for Type 2 Diabetes

WANG Han, HOU Dianzhi, FU Yongxia, ZHAO Qingyu, SHEN Qun   

  1. (National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, National Engineering Research Center for Fruits and Vegetables Processing, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China)
  • Online:2022-05-15 Published:2022-05-27

摘要: 近年来,许多研究表明谷物蛋白及其被酶水解后获得的小分子肽(包括二肽基肽酶-4(dipeptidyl peptidase-4,DPP-IV)、胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)、肽YY(peptide YY,PYY)和相关酶等)能作用于2型糖尿病(type 2 diabetes mellitus,T2DM)的治疗靶点,进而改善T2DM。本文在总结国内外有关谷物蛋白和多肽对糖尿病作用研究的基础上,对其未来在防治T2DM上的发展前景进行了展望。

关键词: 谷物;蛋白;多肽;2型糖尿病

Abstract: In recent years, numerous studies have demonstrated that grain proteins and peptides derived from their enzymatic hydrolysis such as dipeptidyl peptidase-4 (DPP-IV), glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and related enzymes can act on the therapeutic targets for type 2 diabetes mellitus (T2DM) and thereby improve T2DM. This article gives a summary of recent research on the beneficial effect of grain proteins and peptides on T2DM, and discusses future prospects for the application of grain proteins and peptides in T2DM treatment.

Key words: grains; proteins; peptides; type 2 diabetes mellitus

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