食品科学 ›› 2023, Vol. 44 ›› Issue (3): 278-287.doi: 10.7506/spkx1002-6630-20220225-220

• 专题论述 • 上一篇    下一篇

食源性生物活性肽对2型糖尿病的干预作用及其机制研究进展

张舒,王长远,张东杰   

  1. (1.黑龙江八一农垦大学食品学院,黑龙江?大庆 163319;2.国家杂粮工程技术研究中心,黑龙江?大庆 163319;3.黑龙江省农产品加工与质量安全重点实验室,黑龙江?大庆 163319)
  • 出版日期:2023-02-15 发布日期:2023-02-28
  • 基金资助:
    “十三五”国家重点研发计划重点专项(2018YFE0206300);黑龙江省自然科学基金研究团队项目(TD2020C003); 2022年中央引导地方科技发展专项(DQKJJYD0001)

Ameliorative Effect and Mechanism of Food-Derived Bioactive Peptides against Type 2 Diabetes Mellitus: A Review

ZHANG Shu, WANG Changyuan, ZHANG Dongjie   

  1. (1. College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China; 2. National Coarse Cereals Engineering Research Center, Daqing 163319, China; 3. Key Laboratory of Agro-products Processing and Quality Safety of Heilongjiang Province, Daqing 163319, China)
  • Online:2023-02-15 Published:2023-02-28

摘要: 2型糖尿病属于非胰岛素依赖性糖尿病,全世界每年有数百万人患2型糖尿病或成为潜在患者。食源性活性肽不仅具有基本的营养优势,而且更易被机体吸收,有研究证实生物活性肽可以抑制与2型糖尿病相关的代谢酶活力,促进肠促胰岛素分泌,改善胰岛素抵抗,因此可以作为有效管理该疾病的功能性食品或药物。本文综述了食源性生物活性肽的特性和来源,以及目前其关于调节血糖作用机制的研究进展,归纳了食源性代谢酶调节剂的相关研究,以期为食源性生物活性肽的进一步研究提供参考。

关键词: 功能食品;食物源生物活性肽;2型糖尿病;血糖调控;干预机制

Abstract: Type 2 diabetes mellitus is also called non-insulin-dependent diabetes mellitus. Every year, millions of people around the world suffer from type 2 diabetics or become potential patients. Food-derived bioactive peptides not only provide essential nutritional benefits, but also are more easily absorbed by the body. Previous studies have shown that bioactive peptides can inhibit the activity of metabolic enzymes associated with type 2 diabetes, promote insulin secretion and improve insulin resistance, making them functional foods or drugs for effective management of this disease. In order to provide a reference for further research on food-derived bioactive peptides, this paper reviews the properties and sources of food-derived bioactive peptides and the state of the art in research on the regulatory mechanism of food-derived bioactive peptides on blood glucose levels, and it summarizes the studies on food-derived metabolic enzyme modulators. In order to provide a reference for the innovation of food-derived bioactive peptides.

Key words: functional foods; food-derived bioactive peptides; type 2 diabetes; blood glucose regulation; intervention mechanism

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