食品科学 ›› 2023, Vol. 44 ›› Issue (13): 338-345.doi: 10.7506/spkx1002-6630-20220623-249

• 专题论述 • 上一篇    下一篇

噬菌体在食品微生物安全领域中应用的局限性和挑战

惠潇然,黄振华,刘静,吴倩,许天明,段为旦,潘迎捷,张昭寰,赵勇   

  1. (1.上海海洋大学食品学院,上海 201306;2.农业农村部(上海)水产品贮藏保鲜质量安全风险评估实验室,上海 201306;3.上海水产品加工及贮藏工程技术研究中心,上海 201306)
  • 出版日期:2023-07-15 发布日期:2023-08-11
  • 基金资助:
    上海市优秀学术带头人计划资助项目(21XD1401200);国家自然科学基金面上项目(31972188); 上海市自然科学基金项目(22ZR1427500)

Limitations and Challenges of the Application of Phages in the Field of Microbial Food Safety

HUI Xiaoran, HUANG Zhenhua, LIU Jing, WU Qian, XU Tianming, DUAN Weidan, PAN Yingjie, ZHANG Zhaohuan, ZHAO Yong   

  1. (1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; 2. Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Rural Affairs, Shanghai 201306, China; 3. Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China)
  • Online:2023-07-15 Published:2023-08-11

摘要: 近年来,噬菌体控制食品有害微生物的研究日益增多,因其具有宿主特异性,被视为保障食品安全的理想工具。但是,噬菌体在应用时仍存在一系列的局限性,导致其在食品工业生产中的实际应用案例还相对较少。因此,本文针对噬菌体在食品安全中应用的前沿热点问题,重点讨论噬菌体在食品工业中应用的可接受程度、潜在的耐药传播风险、细菌的噬菌体抗性问题、复杂食品基质对其作用效果的影响,并对噬菌体在食品工业中的应用方式提出科学合理的建议,以推动噬箘体的基础研究走向食品工业的实际应用。

关键词: 噬箘体;食品领域;局限性;挑战

Abstract: In recent years, an increasing number of studies have demonstrated the role of phages in controlling harmful microorganisms in foods. Due to their host specificity, phages are considered as an ideal tool to guarantee food safety. However, there are a series of limitations to the application of phages, so there have been few cases of the application of phages in the food industry. In this context, this paper discusses the frontier and hot issues in the application of phages in food safety, with a focus on the acceptability of the application of phages in the food industry, the potential risk of drug resistance transmission, the problem of phage resistance of bacteria, and the influence of complex food matrices on the effect of phages. Moreover, scientific and reasonable suggestions on the application of phages in the food industry are put forward. We hope that this review will promote the shift from basic research on phages to their application in the food industry.

Key words: phage; food field; limitation; challenge

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