食品科学 ›› 2023, Vol. 44 ›› Issue (15): 278-297.doi: 10.7506/spkx1002-6630-20230220-186

• 专题论述 • 上一篇    

功能活性因子对机体白色和棕色脂肪组织的调控机理研究进展

谈婷,罗毅皓,孙万成   

  1. (青海大学农牧学院,青海 西宁 810016)
  • 发布日期:2023-09-01
  • 基金资助:
    国家自然科学基金地区科学基金项目(22167020)

Research Progress in the Regulation Mechanisms of White and Brown Adipose Tissue in the Body by Functionally Active Factors

TAN Ting, LUO Yihao, SUN Wancheng   

  1. (College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China)
  • Published:2023-09-01

摘要: 棕色脂肪组织(brown adipose tissue,BAT)能够通过促进能量消耗改善机体代谢水平,有助于肥胖和糖尿病等代谢性疾病的预防和治疗,BAT现已成为治疗代谢疾病的新靶点。目前有关机体BAT活性提高的研究既是热点也是难点,对食品中调节BAT的功能活性因子的研究与分析有助于研发新型营养激活剂。本文对BAT的发展和产热机制以及产热相关功能活性因子进行总结,同时对食品中调节棕色脂肪的活性成分及其调节机制进行综述,并简要介绍白色脂肪组织(white adipose tissue,WAT)和BAT对机体健康的影响,通过探究BAT调节机体能量代谢平衡和机体各种疾病的研究进展,为未来研发棕色脂肪营养激活剂、完善个体化健康膳食管理方案和防治疾病提供理论依据。

关键词: 棕色脂肪组织;产热基因;活性因子;机体健康

Abstract: Brown adipose tissue (BAT) improves the metabolic level of the body by promoting energy expenditure, which can contribute to the prevention and treatment of metabolic diseases such as obesity and diabetes, and BAT has become a new target for the treatment of metabolic diseases. BAT activity enhancement in the body is a hot topic but also a challenge for researchers, and research and analysis of functionally active factors in foods that regulate BAT can help to develop new nutritional activators. In this paper, we summarize the development and thermogenesis of BAT and thermogenesis-related factors, and review active ingredients in foods that regulate brown fat and their mechanisms of action, and briefly introduce the effects of white adipose tissue (WAT) and BAT on the body’s health. We also discuss recent developments in understanding the role of BAT in regulating energy metabolic balance and various diseases in the body. We hope that the present review will provide a theoretical basis for future development of brown adipose nutritional activators and improvement of individualized healthy dietary management programs in order to prevent and treat various diseases.

Key words: brown adipose tissue; thermogenesis-related genes; active factors; physical health

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