食品科学 ›› 2008, Vol. 29 ›› Issue (10): 586-592.

• 营养卫生 • 上一篇    下一篇

食品包装材料中残留物全氟辛酸盐毒理学研究

 王利兵, 赵青, 李灼坤, 徐丽广, 胥传来   

  1. 江南大学食品学院; 天津出入境检验检疫局;
  • 出版日期:2008-10-15 发布日期:2011-12-08

Study on Toxicology of Ammonium Perfluorooctanoate in Food Packaging Materials

 WANG  Li-Bing, ZHAO  Qing, LI  Zhuo-Kun, XU  Li-Guang, XU  Chuan-Lai   

  1. 1.School of Food Science and Technology,Jiangnan University,Wuxi 214122,China; 2.Tianjin Entry-Exit Inspection and Quarantine Bureau,Tianjin 300453,China
  • Online:2008-10-15 Published:2011-12-08

摘要: 实验选取全氟辛酸盐类中具有代表性的全氟辛酸氨(APFO)进行毒性和部分慢性毒性实验研究,得出如下全氟辛酸盐毒理学结论:急性经口毒性LD50值为584mg/kg,95%可信限为430~794mg/kg;值为70mg/L;轻刺激性物质;生殖细胞致突变物,具有生殖毒性,单次剂量接触APFO和重复剂量接触APFO均可引起大鼠和小鼠的肝肿大和肝脏的病理改变;肝组织和血清中PFOA的检测结果进一步证明了该类物质具有靶器官毒性和生殖毒性。

关键词: 食品, 包装材料, 全氟辛酸铵, 毒理学

Abstract: For ammonium perfluorooctanoate (APFO),a representative substance of perfluorooctane salts,the acute oral toxicity of rat LD50 is 584 mg/kg with 95% reliability (430~94 mg/kg). It is a slight skin irritant substance,with reproductive toxicity,germ cell mutagenicity,specific target organ systemic toxicity of single exposure and repeated exposure. The detection results of APFO in liver and serum also prove its specific target organ systemic toxicity and reproductive toxicity.

Key words: food, packaging materials, APFO, toxicology