食品科学 ›› 2008, Vol. 29 ›› Issue (12): 658-662.

• 营养卫生 • 上一篇    下一篇

白苏油对非酒精性脂肪肝作用的研究

 蒋利和, 史岩, 张玉芳, 古二超, 杨志荣   

  1. 四川大学生命科学院,生物资源与生态环境教育部重点实验室; 广西大学科技处;
  • 出版日期:2008-12-15 发布日期:2011-12-08

Effects of Perilla frutescens(linn) Britt Seed Oil on Nonalcoholic Fatty Liver in Rat

 JIANG  Li-He, SHI  Yan, ZHANG  Yu-Fang, GU  二Chao, YANG  Zhi-Rong   

  1. 1.College of Life Sciences,Sichuan University,Key Laboratory of Bio-resources and Eco-environment,Ministry of Education, Chengdu 610064,China;2.Sience and Technology Division,Guangxi University,Nanning 530004,China
  • Online:2008-12-15 Published:2011-12-08

摘要: 实验用超临界CO2萃取法从白苏种子提取得白苏油,并用白苏油对非酒精性脂肪肝进行研究,结果表明,白苏油能显著降低非酒精性脂肪肝大鼠血清和肝脏丙氨酸转换酶(ALT)及谷草氨基酸转换酶(AST)的活性,减少丙二醛(MDA)、总甘油三脂(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-c)的含量及肝脏指数,提高高密度脂蛋白胆固醇(HDL-c)的含量和超氧化歧化酶(SOD)的活性,组织切片也显示了白苏油良好的治疗效果。结果表明:一定量的白苏油具有调节血脂保护肝脏的作用,其机制可能与抗氧化有关。

关键词: 超临界CO2, 气相色谱-质谱联用, 白苏油, 非酒精性脂肪肝

Abstract: Perilla frutescens(linn) Britt seed oil(PO) was extracted with supercritical-CO2 method. This study aimed to evaluate the effects of PO on nonalcoholic fatty liver. The results showed that the PO significantly lowers the activities of aminotransferase(AST),and alanise aminonsferase(ALT),and reduces the contents of malondialdeh1yde(MDA),total Cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-c),the peroxidation product,malondialdehyde(MDA) and liver indexes and elevates the activity of superoxide dismutase(SOD) and high density lipoprotein cholesterol(HDL-c) in serum and liver of male Wistar rats. Histological examination is consistent with physiological indicators. In conclusion the PO can be proposed to protect the liver against fatty liver in rats,and the protective effect on liver may be correlated with its antioxidant and free radical scavenger effects.

Key words: supercritical-CO2 extraction, GC-MS, Perilla frutescens(linn) Britt seed oil, nonalcoholic fatty liver