食品科学 ›› 2005, Vol. 26 ›› Issue (8): 384-386.
• 营养卫生 • 上一篇 下一篇
辛晓林, 杨立红, 黄清荣, 冯芹
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XIN Xiao-Lin, YANG Li-Hong, HUANG Qing-Rong, FENG Qin
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摘要： 目的:研究藻蓝蛋白对心肌收缩活动的影响,并探讨其作用机理。方法:采用斯氏离体蛙心灌流方法,观察藻蓝蛋白对心肌收缩力和心率的影响。结果:三个浓度(1.2、4.5、8.4μg/ml)的藻蓝蛋白均能增强离体蛙心心肌收缩力(p<0.01),但未见其对心率的影响。心得安、异搏定均能拮抗藻蓝蛋白(8.4μg/m)的效应。结论:藻蓝蛋白具有正性肌力作用,其机制与兴奋心肌细胞膜上β受体及激活细胞膜上Ca2+通道有关。
关键词: 藻蓝蛋白, 心脏, 正性肌力, &beta, 受体, Ca2+通道
Abstract: Objective: To study the effect of phycocyanin on myocardial contraction action of isolated toad heart and the mechanism involved in this action. Methods: Isolated toad heart model produced by Straub’method was used to observe the change of myocardial contraction force and cardiac rate after phycocyanin were used. Results: At three concentration (1.2, 4.5, 8.4μg /ml)the myocardial contraction force increased extremely strikingly (p<0.01),But didn’t show the effect on toad cardiac rate. Propranolol and verapamil antagonized the effectof phycocyanin (8.4μg /ml). Conclusions: The main effects of phycocyanin were that it haspositive inotropic action, the mechanism of the action might be related to the excitation of β-receptor and calcium channel.
Key words: phycocyanin, heart, positive inotropic action, β-receptor, calcium channel
辛晓林, 杨立红, 黄清荣, 冯芹. 藻蓝蛋白对离体蟾蜍心脏正性肌力作用研究[J]. 食品科学, 2005, 26(8): 384-386.
XIN Xiao-Lin, YANG Li-Hong, HUANG Qing-Rong, FENG Qin. A Study on the Positive Inotropic Action of Phycocyanin on Isolated Toad Heart[J]. FOOD SCIENCE, 2005, 26(8): 384-386.
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