大枣多肽裂解液抗肿瘤作用研究

食品科学 ›› 2008, Vol. 29 ›› Issue (11): 597-600.

大枣多肽裂解液抗肿瘤作用研究

孙秀娥, 曹柏营, 昌友权, 郑鸿雁

吉林工程技术师范学院生物与食品工程学院；吉林农业大学食品工程学院；

出版日期:2008-11-15 发布日期:2011-12-08

Experimental Study on Antitumor Effect of Jujube Peptide Prepared with Electromagnetic Cracking Device

SUN Xiu-E, CAO Bai-Ying, CHANG You-Quan, ZHENG Hong-Yan

1.College of Biology and Food Engineering,Jilin Teachers’Institute of Engineering and Technology,Changchun 130052,China;2.College of Food Engineering,Jilin Agricultural University,Changchun 130118,China

Online:2008-11-15 Published:2011-12-08

摘要/Abstract

摘要： 目的:探讨大枣多肽裂解液抗肿瘤作用并初步探讨其抗肿瘤机制,为其临床应用提供实验室依据。方法:将接种肿瘤后的小鼠随机分为5组,每组10只小鼠,雌雄各半,给药10d,停药后24h处死动物,称小鼠体重,剥离小鼠右腋下皮下组织,摘出肿瘤,称瘤重,测定生化指标。结果:对肉瘤(S180)、肝癌(Hep)、胃癌(MFC)细胞荷瘤小鼠肿瘤生长具有明显的抑制作用,其中对S180作用显著,较低剂量即可显示明显作用,延长S180荷瘤鼠生存时间;同时可增加吞噬指数α、廓清指数K、及胸腺系数;对体外淋巴细胞转化功能亦有增强作用。结论:大枣多肽裂解液具有明显抗肿瘤活性。

关键词: 大枣多肽裂解液, 抗肿瘤, 免疫作用

Abstract: Objective:To study the antitumor effect of jujube peptide perpared by using electromagnetic cracking device.Method:The selected mice were inoculated with tumor cells and divided into 5 groups randomly(n=10),half male and half female,which were administered with the jujube peptide for 10 d continuously.The mice were killed and weighed at the 24th h after the last administration,and the tumors at right axillary fossa were separated.Results:The jujube peptide obviously inhibits the growth of S180,Hep and MFC cells in tumor bearing mice.It can suppress the growth of S180 more significantly and prolong the survival time of the S180 bearing mice even at lower dose.Meanwhile,it can increase the phagocytic index α,clearance index K,thymus coefficient and enhance the transformation function of lymphocyte in vitro.Conclusion:The jujube peptide has obvious antitumor effect.

Key words: jujube peptide perpared by using electromagnetic cracking device, antitumor, immunity

孙秀娥, 曹柏营, 昌友权, 郑鸿雁. 大枣多肽裂解液抗肿瘤作用研究[J]. 食品科学, 2008, 29(11): 597-600.

SUN Xiu-E, CAO Bai-Ying, CHANG You-Quan, ZHENG Hong-Yan. Experimental Study on Antitumor Effect of Jujube Peptide Prepared with Electromagnetic Cracking Device[J]. FOOD SCIENCE, 2008, 29(11): 597-600.

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