食品科学 ›› 2020, Vol. 41 ›› Issue (7): 275-282.doi: 10.7506/spkx1002-6630-20190330-392

• 专题论述 • 上一篇    下一篇

植物多糖的抗肿瘤活性研究进展

边亮,陈华国,周欣   

  1. (贵州师范大学 贵州省山地环境信息系统与生态环境保护重点实验室,贵州省药物质量控制及评价技术工程实验室,天然药物质量控制中心,贵州 贵阳 550001)
  • 出版日期:2020-04-15 发布日期:2020-04-20
  • 基金资助:
    国家自然科学基金面上项目(31570358);贵州省科技计划项目(黔科合支撑[2018]2826); 贵州省高层次创新人才培养项目(黔科合人才(2015)4033号); 贵州省优秀青年科技人才项目(黔科合平台人才[2017]5625); 贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]065)

Recent Advances in Understanding the Antitumor Activity of Polysaccharides from Plants

BIAN Liang, CHEN Huaguo, ZHOU Xin   

  1. (Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine,Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China)
  • Online:2020-04-15 Published:2020-04-20

摘要: 植物多糖作为一种具备多种生物活性的天然产物,因其具备高效、低毒等优势成为食品抗肿瘤领域的研究热点。研究发现,植物多糖应用于抗肿瘤临床实验中,有助于解除免疫抑制,增强免疫应答,抑制肿瘤的生长、侵袭及转移。本文主要概括了近10 年来国内外抗肿瘤植物多糖的种类,从直接抗肿瘤作用、调控肿瘤微环境、红细胞免疫、铁代谢4 个方面阐述了植物多糖的抗肿瘤作用机制,并讨论了植物多糖抗肿瘤的构效关系,对植物多糖抗肿瘤的研究方向进行展望,以期促进植物多糖的深入研究,为抗肿瘤食品的研发提供理论参考。

关键词: 植物多糖, 抗肿瘤, 作用机制

Abstract: As a class of natural products with many biological activities, plant polysaccharides have become a research hotspot in the field of anti-tumor functional foods because of their advantages of high efficiency and low toxicity. Clinical anti-tumor trials have demons plant polysaccharides can alleviate immunosuppression, enhance immune response, and inhibit the growth, invasion and metastasis of tumors.?In this review, the anti-tumor plant polysaccharides that have been reported over the decade are summarized. The anti-tumor mechanisms of plant polysaccharides are elucidated from four perspectives: regulation of tumor microenvironment, targeted cancer cell therapy, iron metabolism and erythrocyte immunity. Finally, the structure-activity relationship of anti-tumor plant polysaccharides is also discussed, and future research directions are presented in order to promote in-depth studies of plant polysaccharides and provide a theoretical basis for the research and development of anti-cancer foods.

Key words: plant polysaccharides, antitumor, mechanism

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