食品科学 ›› 2025, Vol. 46 ›› Issue (16): 13-24.doi: 10.7506/spkx1002-6630-20241219-163

• 预防便秘促进肠道健康专栏 • 上一篇    

肠道微生物与功能性便秘:发生机制及营养干预进展

段昊,刘改改,路佳敏,李阳,常新悦,杨天宇,包书源,松伟,闫文杰   

  1. (1.北京联合大学生物化学工程学院,生物活性物质与功能食品北京市重点实验室,北京 100023;2.北京联合大学应用文理学院,保健食品功能检测中心,北京 100191;3.中南大学湘雅公共卫生学院,湖南 长沙 410083)
  • 发布日期:2025-07-22
  • 基金资助:
    “十四五”国家重点研发计划项目(2023YFF1103802)

Gut Microbiota and Functional Constipation: Recent Advances in Pathogenesis and Nutritional Interventions

DUAN Hao, LIU Gaigai, LU Jiamin, LI Yang, CHANG Xinyue, YANG Tianyu, BAO Shuyuan, SONG Wei, YAN Wenjie   

  1. (1. Beijing Key Laboratory of Bioactive Substances and Functional Food, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China; 2. Functional Inspection Center of Health Food, College of Applied Sciences and Humanities, Beijing Union University, Beijing 100191, China; 3. Xiangya School of Public Health, Central South University, Changsha 410083, China)
  • Published:2025-07-22

摘要: 随着人口老龄化的加剧,功能性便秘的问题日益突出,严重影响老年人的生活质量。当下聚焦于老年群体探究功能性便秘的发生机制及营养干预的策略研究较多,但缺乏系统综述。因此,本文重点讨论了肠道微生物代谢产物与功能性便秘发生的关联性,对目前已获批准用于润肠通便保健食品中的原料进行了详细的整理和数据统计,并对这些原料进行了系统的梳理和分类,进一步对其改善便秘的作用机制进行了分析,以期为老年功能性便秘的相关功能食品研发及科研工作提供一定的启示和帮助。

关键词: 老年;功能性便秘;肠道微生物代谢物;作用机制;原料;保健食品

Abstract: With the acceleration of population aging, the problem of functional constipation has become increasingly prominent, significantly affecting the quality of life of the elderly. Currently, there are numerous studies focusing on the pathogenesis of and nutritional interventions in functional constipation in the elderly population. However, systematic reviews are lacking. Therefore, this paper focuses on discussing the correlation between gut microbial metabolites and the occurrence of functional constipation, and presents a systematic summary and classification of the raw materials that have been approved for use in health foods for moistening the intestine and promoting defecation. Furthermore, their mechanisms of action in alleviating constipation are discussed. This review is expected to provide enlightenment and assistance for the research and development of functional foods against functional constipation in the elderly.

Key words: elderly; functional constipation; gut microbiota metabolites; mechanism of action; raw materials; health foods

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