食品科学 ›› 2025, Vol. 46 ›› Issue (15): 373-346.doi: 10.7506/spkx1002-6630-20250109-063

• 专题论述 • 上一篇    下一篇

类器官技术在缓解视觉疲劳类功能食品研发中的应用进展

张绍时,段昊,赵建,郭豫,闫文杰   

  1. (1.北京联合大学生物化学工程学院,生物活性物质与功能食品北京市重点实验室,北京 100023;2.北京联合大学应用文理学院,保健食品功能检测中心,北京 100191)
  • 出版日期:2025-08-15 发布日期:2025-07-22
  • 基金资助:
    “十四五”国家重点研发计划重点专项(2023YFF1103802)

Application of Organoid Technology in the Development of Health Foods to Alleviate Visual Fatigue

ZHANG Shaoshi,, DUAN Hao, ZHAO Jian,, GUO Yu,, YAN Wenjie   

  1. (1. Beijing Key Laboratory of Bioactive Substances and Functional Food, College of Biochemical Engineering, Beijing Union University, Beijing 100023, China;2. Functional Testing Center of Health Food, College of Applied Arts and Science, Beijing Union University, Beijing 100191, China)
  • Online:2025-08-15 Published:2025-07-22

摘要: 眼部健康已成为国民健康的重要组成部分。随着公共卫生条件的改善,视觉疲劳问题已经成为眼部健康的关注重点。在此背景下,功能性食品在维护视觉疲劳方面扮演了关键角色。然而,在评估功能食品对缓解视觉疲劳的功效时,面临缺乏动物实验数据支持和人体试食试验主观性强的挑战。本文通过分析眼部健康类功能食品的发展现状、视觉疲劳的多种症状以及与视觉器官的关联,探讨3D类器官技术在模拟眼部组织结构和功能上的显著优势,以及其在建立视觉疲劳模型和探究营养因子干预机制中的应用潜力。最后,基于类器官技术和现有技术瓶颈并结合政策导向,对缓解视觉疲劳相关保健食品的评价体系和功效声称提出新的建议。本文为开发更有效的缓解视觉疲劳、保护眼部健康的保健食品提供了新的研究方向,并强调了类器官技术在推动缓解视觉疲劳领域发展中的重要作用。

关键词: 视觉疲劳;类器官技术;保健食品;功效声称

Abstract: Eye health has become an important part of national health. With the improvement of public health conditions, visual fatigue has become a focus of attention in eye health. In this context, functional foods have played a key role in maintaining visual fatigue. However, there are challenges in evaluating the efficacy of functional foods in relieving visual fatigue, including a lack of data from animal experiments and the subjectivity of human feeding trials. This paper analyzes the current development status of functional foods for eye health, the various symptoms of visual fatigue, and their association with visual organ. It explores the significant advantages of 3D tissue-engineered organoid technology in simulating the structure and function of the eye, and its potential application in establishing visual fatigue models and exploring the mechanisms of nutrient interventions. Finally, based on organoid technology and existing technical bottlenecks combined with the current policy orientation, new suggestions are made for the evaluation system for and efficacy claims on eye health-related functional foods. This article provides a new research direction for developing more effective eye health-protecting functional foods and highlights the important role of organoid technology in driving the development of eye health-protecting functional foods.

Key words: visual fatigue; organoid technology; health foods; efficacy claims

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