脂质体前体的制备及其在食品营养物中的应用

doi:10.7506/spkx1002-6630-201311078

摘要/Abstract

摘要：

脂质体具有良好的生物相容性和可降解性，在药物和食品领域中有着广泛应用，但存在稳定性差的缺点。脂质体前体的制备可有效克服这一问题，同时在保持给药过程中微粒的完整性、提高营养物溶解性和生物利用度、促进营养物胃肠吸收、促进营养物膜渗透能力、药物动力学等方面也有巨大的潜力。本文介绍近年来脂质体前体的制备方法和特点以及其在食品营养物方面应用的进展，以期为脂质体前体的研究提供一定的参考。

关键词: 脂质体前体, 制备, 食品营养物

Abstract:

Liposome has been widely investigated in the field of food nutrient and drug delivery due to its biocompatible
and biodegradable properties. However, liposome has a poor stability such as aggregation, and susceptibility to hydrolysis
and oxidation. Production of proliposome can be effectively overcome this problem, while maintaining the integrity of the
particles in the administration process, improving the solubility and bioavailability of nutrients, enhancing the gastrointestinal
absorption of nutrients, increasing the permeability of nutrients to cytomembrane, and modifying the pharmacokinetics. This
review mainly introduces the recent advances on the study of the preparation methods and characteristics of proliposome,
and lists the petential applications of proliposome in food nutrients.

Key words: proliposome, preparation, food nutrients

中图分类号:

贾竞夫，忻娜，王燕，赵亚平. 脂质体前体的制备及其在食品营养物中的应用[J]. 食品科学, 2013, 34(11): 375-380.

JIA Jing-fu，XIN Na，WANG Yan，ZHAO Ya-ping. Preparation of Proliposome and Its Application in Food Nutrients[J]. FOOD SCIENCE, 2013, 34(11): 375-380.

参考文献

[1]杨彤,谢庆君.新型脂质体的研究进展[J].第19届全国儿科药学学术会议,2008,:-
[2]GUPTA S, SINGH R P, LOKWANI P, et al..Vesicular system as targeted drug delivery system: An overview.[J].International Journal of Pharmacy and Technology,2011,:-
[3]冯炜玮.[J].陈志伟, 固体脂质体纳米粒制备方法的研究进展. 中国医药生物技术,2011,:-
[4]李勇.[J].曲韵智, 李津明等. 纳米结构脂质载体的研究进展. 黑龙江医药,2009,:-
[5]MUSTHABA S M.[J].BABOOTA S, AHMED S, et al. Status of novel drug delivery technology for phytotherapeutics. Expert Opinion on Drug Delivery,2009,:-
[6]PAYNE N I.[J].TIMMINS P, AMBROSE C V. Proliposomes: A novel solution to an old problem. Journal of Pharmaceutical Sciences,1986,:-
[7]ELHISSI A.[J].GILL H, AHMED W, et al. Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology. Journal of Liposome Research,2011,:-
[8]VORA B.[J].KHOPADE A J, JAIN N K. Proniosome based transdermal delivery of levonorgestrel for effective contraception. Journal of Controlled Release,1998,:-
[9]JUKANTI R.[J].SHEELA S, BANDARI S, et al. Enhanced bioavailability of exemestane via proliposomes based transdermal delivery. Journal of Pharmaceutical Sciences,2011,:-
[10]WANG D.[J].KONG L, WANG J, et al. Polymyxin E sulfate-loaded liposome for intravenous use: Preparation, lyophilization, and toxicity assessment in vivo. PDA Journal of Pharmaceutical Science and Technology,2009,:-
[11]HIREMATH P S.[J].SOPPIMATH K S, BETAGERI G V. Proliposomes of exemestane for improved oral delivery: Formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine. International Journal of Pharmaceutics,2009,:-
[12]PAYNE N I.[J].COSGROVE R F, GREEN A P, et al. In-vivo studies of amphotericin B liposomes derived from proliposomes: Effect of formulation on toxicity and t disposition of the drug in mice. Journal of Pharmacy and Pharmacology,1987,:-
[13]宋金春.[J].刘薇芝, 黄岭. 葛根素前体脂质体的制备及体外性质研究. 中国药学杂志,2007,:-
[14]XU H.[J].HE L, NIE S, et al. Optimized preparation of vinpocetine proliposomes by a novel method and in vivo evaluation of its pharmacokinetics in New Zealand rabbits. Journal of Controlled Release,2009,:-
[15]BATZRI S.[J].KORN E D. Single bilayer liposomes prepared without sonication. BBA - Biomembranes,1973,:-
[16]ELHISSI A M A.[J].O'NEILL M A A, ROBERTS S A, et al. A calorimetric study of dimyristoylphosphatidylcholine phase transitions and steroid-liposome interactions for liposomes prepared by thin film and proliposome methods. International Journal of Pharmaceutics,2006,:-
[17] 杨立平. 冷冻干燥法制备α-细辛脑前体脂质体. 中国药师, 2005. 8(7): p. 570-572
[18]王志宣.[J].邓英杰, 张晓鹏等. 尼莫地平前体脂质体的制备及其质量评价. 沈阳药科大学学报,2006,:-
[19]GLAVAS-DODOV M.[J].FREDRO-KUMBARADZI E, GORACINOVA K, et al. The effects of lyophilization on the stability of liposomes containing 5-FU. International Journal of Pharmaceutics,2005,:-
[20]ZHANG J H.[J].ZHU J B. A novel method to prepare liposomes containing amikacin. Journal of Microencapsulation,1999,:-
[21]MOHAMMED A R.[J].BRAMWELL V W, COOMBES A G A, et al. Lyophilisation and sterilisation of liposomal vaccines to produce stable and sterile products. Methods,2006,:-
[22]LIU Y.[J].ZHANG Z Z, SHAO Y J, et al. Preparation of antisense oligodeoxynucleotides-loaded cationic proliposomes and its in vitro characters. Chinese Journal of New Drugs,2010,:-
[23]BAI C.[J].PENG H, XIONG H, et al. Carboxymethylchitosan-coated proliposomes containing coix seed oil: Characterisation, stability and in vitro release evaluation. Food Chemistry,2011,:-
[24]LEI G F.[J].DENG Y J, ZHANG L N, et al. Preparation of breviscapine proliposome by fluidized bed coating method. Chinese Traditional and Herbal Drugs,2006,:-
[25]ALVES G P.[J].SANTANA M H A. Phospholipid dry powders produced by spray drying processing: Structural, thermodynamic and physical properties. Powder Technology,2004,:-
[26]陈骐.[J].黄芸, 顾学裘等. 喷雾干燥法制备前体脂质体的基础研究. 沈阳药科大学学报,1997,:-
[27]WANG M.[J].GAO X L. Study on preparation of a new oleanolic acid proliposomes and its properties. Chinese Pharmaceutical Journal,2007,:-
[28]王梅.[J].高晓黎. 肉苁蓉总苷前体脂质体的研制. 新疆医科大学学报,2007,:-
[29]KUNASTITCHAI S.[J].PICHERT L, SARISUTA N, et al. Application of aerosol solvent extraction system (ASES) process for preparation of liposomes in a dry and reconstitutable form. International Journal of Pharmaceutics,2006,:-
[30]XIA F.[J].JIN H, ZHAO Y, et al. Preparation of coenzyme Q10 liposomes using supercritical anti-solvent technique. Journal of Microencapsulation,2012,:-
[31]XIA F.[J].JIN H, ZHAO Y, et al. Supercritical antisolvent-based technology for preparation of vitamin D3 proliposome and its characteristics. Chinese Journal of Chemical Engineering,2011,:-
[32]XIA F.[J].HU D, JIN H, et al. Preparation of lutein proliposomes by supercritical anti-solvent technique. Food Hydrocolloids,2012,:-
[33]孙珊珊.[J].王慧云, 陆爱华. 全反式维甲酸前体脂质体的制备及磷脂过氧化值的测定. 中国当代医药,2010,:-
[34]杨静文.[J].邓英杰, 李宝齐等. 全反式维甲酸前体脂质体的制备及体外评价. 中国新药杂志,2007,:-
[35]陈建明.[J].张仰眉, 高申等. 维生素A前体脂质体的研制及其特性考察. 第二军医大学学报,2003,:-
[36]ISHIKAWA H.[J].SHIMODA Y, MATSUMOTO K. Preparation of liposomal microcapsules by proliposome method with soybean lecithin. Journal of the Faculty of Agriculture, Kyushu University,2004,:-
[37]祝青哲.[J].夏书芹, 许时婴. 辅酶Q10前体脂质体的研制及其特性研究. 食品工业科技,2008,:-
[38]ISHIKAWA H.[J].SHIMODA Y, MATSUMOTO K. Liposomal microcapsulation of enzymes by proliposome method with chitosan-coating. Journal of the Faculty of Agriculture, Kyushu University,2005,:-
[39]ZHAO L P.[J].XIONG H, PENG H, et al. PEG-coated lyophilized proliposomes: Preparation, characterizations and in vitro release evaluation of vitamin E. European Food Research and Technology,2011,:-
[40]SONG K H.[J].CHUNG S J, SHIM C K. Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts. Journal of Controlled Release,2005,:-
[41]杨志文.[J].杨木华, 夏侯国等. 莪术油前体脂质体的制备及其质量评价. 中国药学杂志,2008,:-
[42]姜素芳.[J].姚瑶, 盛习锋等. 丹皮酚前体脂质体的研制及其特性. 中国医院药学杂志,2008,:-
[43]储茂泉.[J].古宏晨, 刘国杰. 喷雾干燥法制备丹参酮前体脂质体的研究. 中国药学杂志,2002,:-