膳食补充剂荔枝壳原花青素对大鼠排泄物的影响

doi:10.7506/spkx1002-6630-201315055

食品科学

膳食补充剂荔枝壳原花青素对大鼠排泄物的影响

李书艺，吴茜，汪荣，孙智达*，谢笔钧*

华中农业大学食品科学技术学院，湖北武汉 430070

出版日期:2013-08-15 发布日期:2013-09-03
通讯作者: 谢笔钧,孙智达
基金资助:
“十二五”国家科技支撑计划项目(2012BAD31B03)

Effect of Litchi Pericarp Procyanidins as a Dietary Supplement on Excreta of Rats

LI Shu-yi，WU Qian，WANG Rong，SUN Zhi-da*，XIE Bi-jun*

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Online:2013-08-15 Published:2013-09-03
Contact: XIE Bi-jun,SUN Zhi-da

摘要/Abstract

摘要：

以荔枝壳原花青素低聚体(LPOPC)为研究对象，对SD大鼠连续给药1周，给药剂量150mg/(kg·d)。给药期间，收集动物灌胃后第1、2、3、5、7天的排泄物，并分析动物给药前后尿液和粪便性质的改变与差异。结果表明：给药后大鼠尿液的总抗氧化能力显著升高(P＜0.01)，且与尿液中总酚类物质的含量呈现相关性。在电子鼻分析仪中，给药组大鼠的粪便气味响应值明显低于空白组；HS-SPME-GC-MS分析证实，原花青素灌胃后粪便中挥发性物质苯甲醛、4-甲基苯酚等的强度升高，而产生腐败气味的吲哚、4-乙基苯酚等物质的含量则降低。对粪便中原花青素的代谢产物进行鉴定，发现了单体(－)-表儿茶素和m-香豆酸的存在。

关键词: 荔枝壳原花青素, 大鼠, 排泄物, 抗氧化能力, 电子鼻, 气质联用

Abstract:

An increasing amount of attention is being paid to litchi pericarp procyanidins due to its strong antioxidant activity
in vitro and in vivo. Litchi pericarp oligomeric procyanidins (LPOPC) were investigated in this study. SD rats were administered
with LPOPC at the dose of 150 mg/(kg•d) for 1 week. The urine and feces were collected on the 1st, 2nd, 3rd, 5th and 7th day
during LPOPC administration to compare excreta characteristics from the control group. LPOPC administration resulted in
a significant elevation in the T-AOC of rat urine, which was linked to total phenol content. However, the fecal odor of rats
revealed a decreasing trend after the administration of LPOPC as illustrated by electronic nose analysis, which was due to the
reduction in putrefactive products such as indole and 4-ethyl phenol in feces and an increasing amount of volatile compounds
such as benzaldehyde and 4-methyl phenol as identified by HS-SPME-GC-MS. In addition, LC-MS analysis of procyanidin
metabolites in feces suggested that (－)-epicatechin and m-coumaric acid were the major components.

Key words: Litchi pericarp procyanidins, rats, excreta, T-AOC, electronic nose, GC-MS

中图分类号:

TS264.4

李书艺，吴茜，汪荣，孙智达*，谢笔钧*. 膳食补充剂荔枝壳原花青素对大鼠排泄物的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201315055.

LI Shu-yi，WU Qian，WANG Rong，SUN Zhi-da*，XIE Bi-jun*. Effect of Litchi Pericarp Procyanidins as a Dietary Supplement on Excreta of Rats[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201315055.

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膳食补充剂荔枝壳原花青素对大鼠排泄物的影响

Effect of Litchi Pericarp Procyanidins as a Dietary Supplement on Excreta of Rats

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