食品科学 ›› 2020, Vol. 41 ›› Issue (9): 254-262.doi: 10.7506/spkx1002-6630-20190425-334

• 专题论述 • 上一篇    下一篇

酚类化合物干预镉致肝损伤的研究进展

郝日礼,李大鹏   

  1. (山东农业大学食品科学与工程学院,山东省高校食品加工技术与质量控制重点实验室,山东 泰安 271018)
  • 出版日期:2020-05-15 发布日期:2020-05-15
  • 基金资助:
    国家自然科学基金面上项目(31571836);国家自然科学基金青年科学基金项目(31201417); 山东省现代农业产业技术体系蜂产业创新团队项目(SDAIT-24-05);山东省“双一流”建设项目(SYT2017XTTD04)

Recent Progress in Understanding the Protective Effect of Phenolics against Cadmium-Induced Liver Injury

HAO Rili, LI Dapeng   

  1. (Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, Tai’an 271018, China)
  • Online:2020-05-15 Published:2020-05-15

摘要: 镉是环境和食品中常见的一种重金属污染物,会对人体器官尤其是肝脏造成不可逆损伤。研究发现,镉致肝损伤的机制可能与氧化应激的发生有关。酚类化合物普遍存在于植物性膳食中,具有较强的抗氧化能力,近年来,越来越多的研究结果表明,酚类化合物对镉致肝损伤有显著的防治效果。本文综述了酚类化合物干预镉致肝损伤的研究进展,以期为酚类化合物的开发和应用提供理论参考和研究思路。

关键词: 镉, 植物膳食, 酚类化合物, 氧化应激, 肝损伤

Abstract: Cadmium is a common heavy metal pollutant in the environment and foods, which can cause irreversible damage to human organs, especially liver. Previous studies have found that the mechanism of cadmium-induced liver injury may be related to the occurrence of oxidative stress. Phenolic compounds are ubiquitous in plant-based diets and have strong antioxidant capacity. In recent years, more and more studies have shown that phenolic compounds have significant control effects on cadmium-induced liver injury. This paper reviews recent progress in understanding the protective effect of phenolic compounds against cadmium-induced liver injury, in order to provide a theoretical basis and research ideas for the development and application of phenolic compounds.

Key words: cadmium, plant-based diets, phenolics, oxidative stress, liver damage

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